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Quatitation of Neurotransmission using Positron Emission, Tomography : Aging Effects and Changes in Dementia Patients.

使用正电子发射、断层扫描对神经传递进行定量：痴呆患者的衰老效应和变化。

基本信息

批准号：
04836003
负责人：
ITOH Masatoshi
金额：
$ 1.34万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04836003/
关键词：
DOPAMINE POSITRON TOMOGRAPHY NEUROTRANSMISSION DEMENTIA AGING D2 RECEPTOR 神経伝達

项目摘要

A study was initiated to analyze the central neurotransmission mainly of dopamine system of 27 subjects including AD/SDAT snd vascular dementia of multi-infarct type using positron emission tomography(PET). 18F-labeled fluoro-L-dopa(FDOPA) and 11C-labeled YM09151-2(YM), aD2 receptor ligand were successfully labeled in our institution. Sequential PET data collection. was performed using PT931, CTI inc, Knoxville, U.S.A.to recotd tracer accumulation to the striatum. A semi-automated ROI draw routine was developed to identify the striatum that interactively defined the boundary pixels defined on the histogram curves and images simultaneously. The graphical plot was employed to calculate FDOPA influx rate(Ki) for the ROI data using cerebellar radioactivity as input function. The D2 receptor concentration was estimated by uptade ratio of the YM to the striatum and to the cerebellum. The Ki values were found relatively stable and did not show significant age-related chages. The correlation analysis between Ki and severity of dementia as assessed by mini-mental scale revealed significant reduction of Ki associated with the progression of dementia severity. The D2 receptor density was increased in accordance with receptor supersensitivity related to the reduced presynaptic stimuli. This uncoupling between uptake of a tracer by presynaptic neurons and postsynaptic receptors was most noted in vascular patient, where as AD/SDAT patients showed variable trends which may relate to heterogenous origin of this category. We concludes imaging of neurotransmission with positron emission tomography can be a new diagnostic modality to assess nueronal function of individual neurotransmission system in vivo and in humam.

应用正电子发射断层扫描（PET）技术，对27例AD/SDAT和多梗塞型血管性痴呆（VD）患者的中枢神经传递（主要是多巴胺系统）进行了分析。18F标记的氟-L-多巴（FDOPA）和11 C标记的α D2受体配体YM 09151 -2（YM）在本单位被成功标记。连续PET数据收集。使用PT 931（CTI inc，诺克斯维尔，U.S.A.to）记录纹状体的示踪剂积累进行。开发了一种半自动ROI绘制程序，以识别纹状体，该纹状体同时交互定义直方图曲线和图像上定义的边界像素。使用小脑放射性作为输入函数，采用图形图计算ROI数据的FDOPA流入率（Ki）。D2受体浓度通过YM与纹状体和小脑的升高比率来估计。Ki值相对稳定，未显示出明显的年龄相关性变化。Ki与痴呆严重程度之间的相关性分析显示，随着痴呆严重程度的进展，Ki显著降低。D2受体密度的增加与突触前刺激减少相关的受体超敏性一致。这种突触前神经元和突触后受体摄取示踪剂之间的解偶联在血管患者中最为明显，其中AD/SDAT患者显示出可能与这一类别的异质性起源有关的可变趋势。结论：正电子发射断层扫描神经传递成像可作为一种新的诊断方法，以评估个体神经传递系统在体内和人体内的神经功能。