EFFECT OF Ca-SENSING RECEPTOR ACTIVATION ON UREMIA

Ca 敏感受体激活对尿毒症的影响

• 批准号: 10671007
• 负责人: AKIZAWA Tadao
• 金额: $ 1.92万
• 依托单位: WAKAYAMA MEDICAL UNIVERSITY (1999)Showa University (1998)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671007/
• 关键词: renal failure; calcimimetics; Ca-sensing receptor; blood pressure; secondary hyperparathyroidism; osteitis fibrosa; lipid metabolism; 副甲状腺; カルシウム受容体アゴニスト

The activation of Ca-sensing receptor by calcimimetics brought about the following effects on 5/6 nephrectomized rats within 8-weeks treatment period.1. Decrease in systolic blood pressure2. Retardation of the progression of renal failure3. Reduction of total and LDL cholesterol4. Decrease in the urine protein excretion5. Suppression of glomerular sclerosis6. Suppression of tubulo-intestinal impairment7. Suppression of secondary hyperparathyroidism8. Suppression of osteitis fibrosaThese results suggest that abnormality of Ca-sensing receptor plays a significant role not only for the progression of renal bone disease, but also for the progression of renal impairment in experimental renal failure.

通过钙化受体激活CA-感应受体在8周治疗期内对5/6肾切除型大鼠产生以下影响。1。减少收缩压2。肾衰竭进展的延迟3。减少总胆固醇和LDL胆固醇4。减少尿液蛋白排泄5。抑制肾小球硬化症6。抑制tubulo-Intestinal障碍7。抑制继发性甲状旁腺功能亢进8。抑制骨炎纤维疗法的结果表明，ca敏感受体的异常不仅在肾骨疾病的进展中起着重要作用，而且对实验性肾功能衰竭的肾脏损伤进展。

项目成果

Akizawa T and Fukagawa M: "Modulation of parathyroid cell function by calcium ion in health and uremia."Am J Med Sci. 317. 358-362 (1999)

Akizawa T 和 Fukakawa M：“健康和尿毒症中钙离子对甲状旁腺细胞功能的调节。”Am J Med Sci。

Akizawa T: "The role of calcium-sensing receptor in the pathogenesis of hyperparathyroidism"Nephrol Dial Transplant. 14 S-1. 66-67 (1999)

Akizawa T：“钙敏感受体在甲状旁腺功能亢进发病机制中的作用”肾拨号移植。

Fukagawa M,: "Is aplastic osteodystrophy a disease of malnutrition?"Curr Opin Nephrol Hypertens. 9. 363-367 (2000)

Fukakawa M，：“再生障碍性骨营养不良是一种营养不良疾病吗？”Curr Opin Nephrol Hypertens。

Akizawa T: "The role of Ca sensing receptor in the pathogenesis of secondary hyperparathyroidism"Nephrol Dial Transplant. 14(S-1). 66-67 (1999)

Akizawa T：“Ca 感应受体在继发性甲状旁腺功能亢进发病机制中的作用”肾拨号移植。

Akizawa T: "Modulation of parathyroid function by calcium ion in health and uremia"Am J Med Sci. 317. 358-362 (1999)

Akizawa T：“健康和尿毒症中钙离子对甲状旁腺功能的调节”Am J Med Sci。