Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)

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To regress the pathological findings resulted from chronic kidney disease mineral and bone disorder (CKD-MBD), it may be effective to directly inject the active vitamin D or its analogue into parathyroid gland and to systemically administrate vitamin D and/or calcimimetics for enlarged parathyroid gland and high turn-over bone disease. But it is difficult to regress ectopic vascular calcification by these methods. It may be important to prevent inflammatory process and elastin degradation for regression. Further studies are urgently required to clarify this point.