Experimental study for the regression of chronic kidney disease and mineral bone disorder(CKD-MBD)

慢性肾病和矿物质性骨病（CKD-MBD）消退的实验研究

• 批准号: 20590985
• 负责人: AKIZAWA Tadao
• 金额: $ 2.83万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590985/
• 关键词: 慢性腎臓病ミネラル骨代謝異常症; 二次性副甲状腺機能亢進症; 腎性骨異栄養症; 異所性石灰化; 慢性炎症; エラスチン; 慢性腎不全; CKD-MBD; 動脈硬化; カルシウム受容作動薬; bisphosphonate; 線維性骨炎

To regress the pathological findings resulted from chronic kidney disease mineral and bone disorder (CKD-MBD), it may be effective to directly inject the active vitamin D or its analogue into parathyroid gland and to systemically administrate vitamin D and/or calcimimetics for enlarged parathyroid gland and high turn-over bone disease. But it is difficult to regress ectopic vascular calcification by these methods. It may be important to prevent inflammatory process and elastin degradation for regression. Further studies are urgently required to clarify this point.

为了回归由慢性肾脏疾病矿物质和骨骼疾病（CKD-MBD）产生的病理发现，直接将活性维生素D或其模拟直接注入甲状旁腺可能是有效的，并系统地施用了甲状旁腺和高甲状旁腺和高转角骨骨病，并系统地施用维生素D和/或钙化。但是很难通过这些方法回归异位血管钙化。防止炎症过程和弹性降解以进行回归可能很重要。迫切需要进一步的研究来澄清这一点。

项目成果

Direct injection of calcitriol or its analog improves abnormal gene expression in the hyperplastic parathyroid gland in uremia.

直接注射骨化三醇或其类似物可改善尿毒症增生性甲状旁腺的异常基因表达。

• 发表时间: 2008
• 期刊: Am J Nephrol. 28(1)
• 作者: Shiizaki K;Fukagawa M;Yuan Q;Hatamura I;Nii-Kono T;Saji F;Shigematsu T;Akizawa T
• 通讯作者: Akizawa T

Myocardial effects of VDR activators in renal failure.

• DOI: 10.1016/j.jsbmb.2010.03.026
• 发表时间: 2010-07
• 期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 4.1
• 作者: Mizobuchi, Masahide;Nakamura, Hironori;Tokumoto, Masanori;Finch, Jane;Morrissey, Jeremiah;Liapis, Helen;Slatopolsky, Eduardo
• 通讯作者: Slatopolsky, Eduardo

A Vitamin D Analog Inhibits VSMC Mineralization Induced by TNF-α and Phosphate

维生素 D 类似物抑制 TNF-α 和磷酸盐诱导的 VSMC 矿化

• 发表时间: 2010
• 作者: Aoshima Y;et al
• 通讯作者: et al

Elastin Degradation Accelerates Phosphate-Induced Mineralization of Vascular Smooth Muscle Cells

• DOI: 10.1007/s00223-009-9297-8
• 发表时间: 2009-12-01
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Hosaka, Nozomu;Mizobuchi, Masahide;Akizawa, Tadao
• 通讯作者: Akizawa, Tadao

Improvement of impaired calcium and skeletal homeostasis in vitamin D receptor knockout mice by a high dose of calcitriol and maxacalcitol.

• DOI: 10.1016/j.bone.2009.07.013
• 发表时间: 2009-11
• 期刊: Bone
• 影响因子: 4.1
• 作者: K. Shiizaki;I. Hatamura;I. Imazeki;Y. Moriguchi;T. Sakaguchi;F. Saji;E. Nakazawa;S. Kato;T. Akizawa;E. Kusano