Cross talk between the onset of renal osteodystrophy and ectopic vascular calcification

点击翻译按钮获取中文摘要

Representative outcomes of disturbed Ca and phosphate metabolism are renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification. These abnormalities result in systemic pathological changes in dialysis patients, and shorten the survival or deteriorate the health related quality of life. To understand the mechanisms to progress these systemic abnormalities, cross-talk between renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification was investigated. In uremic rats that develop severe secondary hyperparathyroidism with vascular calcification, advanced osteitis fibrosa has been developed, and the strong association among these progressions was observed. By the intervention of direct injection of vitamin D into hyperplastic parathyroid grand recovered the hyperplasia of parathyroid grand as well as the osteitis fibrosa. However this intervention failed to decrease the ectopic vascular calcification. These results suggest that the presence of cross talk in the developing stage between renal osteodystrophy, secondary hyperparathyroidism and ectopic vascular calcification, but this cross talk disappear at the regression process. The precise process of the cross talk should be further evaluated.