ROLE OF TG RICH RIPOPROTEINS IN ATHEROSCLEROSIS

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Unique receptor, apo B48 receptor, was identified in human monocytemacrophages. The receptor binds and internizes chylomoicrons, triglyceride (TG) rich VLDL, and VLDL devoid of apo E, but not acetyl LDL, via a domain in apo B48. The apo B48 receptor differs from the scavenger receptor family and LDL receptor family because it does not bind acetyl LDL and it binds VLDL devoid of apo E by an apo E-independent mechanism Immunohistochemical studies indicate colocalization of anti-apo B48 receptor Ab and monocyte-macrophage specific Ab in human atherosclerotic lesion foam cells. This suggests that apo B48 receptor may contribute to foam cell formation and atherosclerosis in abnormal state with elevated TG-rich lipoproteins.