ROLE OF TG RICH RIPOPROTEINS IN ATHEROSCLEROSIS
ROLE OF TG RICH RIPOPROTEINS IN ATHEROSCLEROSIS
批准号:
10044249
负责人:
TANAKA Akira
金额:
$13.25万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A).
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2000
中文摘要
在人单核巨噬细胞中发现了独有的载脂蛋白B48受体。该受体通过载脂蛋白B48中的一个结构域与富含甘油三酯(TG)的脂蛋白结合并相互作用。对载脂蛋白B48受体的基因序列进行了分析。免疫组织化学研究表明,抗载脂蛋白B48受体抗体和单核巨噬细胞特异性抗体共存于人动脉粥样硬化病变泡沫细胞中。免疫印迹和斑点印迹法检测到载脂蛋白B100在小肠上皮细胞中的表达。提示饮食中的极低密度脂蛋白可能在人的小肠上皮细胞中合成并转化为低密度脂蛋白,即致动脉粥样硬化的脂蛋白。一些临床研究表明,残留物(RLP胆固醇)的增加在动脉粥样硬化的形成中起着重要作用。残留物(RLP胆固醇)被认为是胰岛素抵抗状态的增加。
英文摘要
Unique receptor, apo B48 receptor, was identified in human monocyte-macrophages. The receptor binds and internizes triglyceride(TG)rich Lipoproteins via a domain in apo B48. The apo B48 receptor cDNA sequences were elucidated. Immunohistochemical studies indicate colocalization of anti-apo B48 receptor Ab and monocyte-macrophage specific Ab in human atherosclerotic lesion foam cells. This suggests that apo B48 receptor may contribute to foam cell formation and atherosclerosis in abnormal state with elevated TG-rich lipoproteins.Apo B100 expression in the epithelial cells of small intestine were identified by immunoblotting and dot-blotting of PCR-amplified cDNA.It suggests that dietary VLDL may be synthesized in human small intestine epithelium and converted into LDL, atherogenic lipoprotein.Some cinical studies showed that increase of remnants(RLP cholesterol), especially in postprandial state, has an important role in developimg atherosclerosis.Remnants(RLP cholesterol)were indicated to increases in the state of insulin resistance.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Bradley WA, Gianturco SH, et al: "Antipeptide antibodies reveal interrelationship of MBP200 and MBP235: unique apo B-48 receptors for lipoproteins on human monocyte-macrophages"J Lipid Res.. 40. 744-752 (1999)
Bradley WA、Gianturco SH 等人:“抗肽抗体揭示了 MBP200 和 MBP235 的相互关系:人单核细胞巨噬细胞上脂蛋白的独特 apo B-48 受体”J Lipid Res.. 40. 744-752 (1999)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Abbasi F, Tanaka A, Reaven GM, et al: "Fasting remnant lipoprotein cholesterol and triglyceride concentrations are evaluated in non-diabetic, insulin resistent, female volunteers"J Chin. Endcrinol. Metab. 84. 3903-3906 (1999)
Abbasi F、Tanaka A、Reaven GM 等人:“在非糖尿病、胰岛素抵抗女性志愿者中评估空腹残余脂蛋白胆固醇和甘油三酯浓度”J Chin。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Marcoux C, Cohn JS, et al: "Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III hyperlipoproteinemic patients"J Lipid Res. 40. 636-647 (1999)
Marcoux C、Cohn JS 等人:“通过免疫亲和凝胶从 III 型高脂蛋白血症患者血浆中分离出的残留样颗粒的表征”J Lipid Res。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Akio Kawakami,Akira Tanaka, et al: "Role of Remnant lipoproteins in Atherosclerosis."Ann.N.Y.Acad.Sci.. 902. 352-356 (2000)
Akio Kawakami、Akira Tanaka 等人:“残余脂蛋白在动脉粥样硬化中的作用。”Ann.N.Y.Acad.Sci.. 902. 352-356 (2000)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Abbasi F,Tanaka A,Reaven GM, et al: "Fasting remnant lipoprotein cholesterol and triglyceride concentrations are evaluated in non-diabetic, insulin resistent, female volunteers"J Clin.Endcrinol.Metab. 84. 3903-3906 (1999)
Abbasi F、Tanaka A、Reaven GM 等人:“在非糖尿病、胰岛素抵抗女性志愿者中评估空腹残余脂蛋白胆固醇和甘油三酯浓度”J Clin.Endcrinol.Metab。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 25 条
Mathematical Analyses on Sampling Theorems in Reproducing Kernel Hilbert Spaces
-
批准号:24500001
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:TANAKA Akira
-
依托单位:
The evaluation method for the effect of the various unnatural video components on viewers using physiological indices.
-
批准号:23500146
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:TANAKA Akira
-
依托单位:
Development of the diet therapy considering polymorphisms of metabolic syndrome related gene
-
批准号:21500794
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:TANAKA Akira
-
依托单位:
Mathematical Properties of Sampling and Optimal Reproducing Kernels
-
批准号:21700001
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:TANAKA Akira
-
依托单位:
Change and Expansion of Japanese-Style Interfirm System in East Asian Automobile and Iron-and-Steel Industry
-
批准号:18530285
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.61万
-
财政年份:2006
-
负责人:TANAKA Akira
-
依托单位:
Mathematical Analyses of Reproducing Kernel Hilbert Spaces for Machine Learning
-
批准号:18700001
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.39万
-
财政年份:2006
-
负责人:TANAKA Akira
-
依托单位:
INTRAVENOUS GENE THERAPY FOR FAMILIAL HYPERCHOLESTEROLEMIA USING LIGAND-FACILITATED TRANSFER OF A LIPOSOME : LDL RECEPTOR GENE COMPLEX
-
批准号:13671178
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2001
-
负责人:TANAKA Akira
-
依托单位:
Transport of marine substance from sea to coastal farm land.
-
批准号:12460108
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.48万
-
财政年份:2000
-
负责人:TANAKA Akira
-
依托单位:
ROLE OF TG RICH RIPOPROTEINS IN ATHEROSCLEROSIS
-
批准号:10671059
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1998
-
负责人:TANAKA Akira
-
依托单位:
STUDY ON THE BIOORGANIC CHEMISTRY OF THE ANTITUMOR ANNONACEOUS ACETOGENINS IN CHINESE ANNONACEAE
-
批准号:10660117
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1998
-
负责人:TANAKA Akira
-
依托单位:
Gene regulation and cell differentiation of FGF8
-
批准号:09670235
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:TANAKA Akira
-
依托单位:
Growth of InAsSb alloy layrs by compositional conversition and its application to mid-infrared sensing devices
-
批准号:08650376
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
-
负责人:TANAKA Akira
-
依托单位:
Historical Studies of the Iwakura Mission in the Early Years of Meiji era
-
批准号:07610342
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1995
-
负责人:TANAKA Akira
-
依托单位:
トランスジェニックマウスを用いた肝臓切除におけるエネルギー代謝の研究-遺伝子治療の肝臓外科への導入
-
批准号:06454384
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.48万
-
财政年份:1994
-
负责人:TANAKA Akira
-
依托单位:
Developmet of Clye cleavano with near-infrared tissue spectroscopy
-
批准号:05557060
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:1993
-
负责人:TANAKA Akira
-
依托单位:
Environment and Development of Shallow Sea and Tidal-Lowland.
-
批准号:03045040
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$3.46万
-
财政年份:1991
-
负责人:TANAKA Akira
-
依托单位:
Studies on metastatic pattern of gastric cancer and useful for immunohistochemical staining of laminin
-
批准号:03670647
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$0.32万
-
财政年份:1991
-
负责人:TANAKA Akira
-
依托单位:
Studies on the counteracting function of crop plants against adverse root environment ( with special emphasis on aluminum toxicity)
-
批准号:59430020
-
项目类别:Grant-in-Aid for General Scientific Research (A)
-
资助金额:$16.38万
-
财政年份:1984
-
负责人:TANAKA Akira
-
依托单位: