Roles of a rachidonic acid cascade in radicular pain induced by herniated nucleus pulposus in the rat

它已经显示出，在Lumb神经根上重新定位了自动核脉冲，使老鼠在时间依赖和可逆的机械超声波中产生了一种与疼痛相关的行为，这是一种思考如何成为周围神经病理学疼痛模型中与疼痛相关的行为。“这一研究的目的是检验其作用的leukocyte和生物学上活性物质包括在arachidonic acid cascade中的病理学机制的激进疼痛的目的”。在大鼠与nitorgen Mustard诱导的lekocytopenia，而Nucleus pulposus产生了其他机械超细胞，但不是一个基本的炎症细胞。神经病理性疼痛是由核细胞引起的，当放置在神经根上时，可能与神经根的重新定位相关的炎症细胞渗透诱导的，可能与神经根的重新定位相关的炎症细胞渗透诱导的重新定位的核细胞细胞渗透比核细胞渗透本身。生物活性物质如前列腺素、thrombox ... More A、白血病和cyclooxygenase-2（COX-2）中的代谢物是在亚拉奇酮酸级联中加入的，在从患者身上发现的晚期磁盘样本中发现的。Thromboxane A y D22 y D2 （TXA y D22 y D2） synthase inhibitor， leukotriene B y D24 y D2 （LTB y D24 y D2） receptor antagonist and COX-2 inhibitor， which were injected into the epidManagement space， resulted in decrease of mechanical hyperalgesia3 and 7 days after epidManagement injection。炎症反应和颗粒化问题在注射后的7天内没有出现。如果TXA-D22-LTB-D24-D2和COX-2是可能的，那么在神经根周围产生了炎症细胞，并通过应用于大鼠神经根中的核脉冲在机械超自然细胞中扮演了一个重要的角色。Epidural injection of LTB D24受体拮抗剂， TXA D22受体D2 synthase inhibitor and/or COX-2 inhibitor may be therapeutically useful， and may attenuate painful radiculopathy due to lumbar disc herniation。Less（低）

It has been shown that autologous nucleus pulposus relocated on the lumbar nerve root in rats produces time dependent and reversible mechanical hyperalgesia which is thought to be an pain related behavior in peripheral neuropathic pain models. The purpose of this study were to examine the roles of leukocyte and biologically active substances including in the arachidonic acid cascade in pathophysiological mechanisms of radicular pain induced by the herniated nucleus pulposus. In rats with nitorgen mustard induced lekocytopenia, the nucleus pulposus produced neither mechanical hyperalgesia nor abundant inflammatory cells. Neuropathic pain produced by the nucleus pulposus, when placed on the nerve root, may be related to inflammatory cell infiltration induced by relocation of the nerve root, may be related to inflammatory cell infiltration induced by relocation of the nucleus pulposus rather than the nucleus pulposus it self. Biologically active substances such as prostaglandins, thrombox … More anes, leukotriences, and cyclooxygenase-2 (COX-2) which are metabolites involved in the arachidonic a acid cascade, are detected in herniated disc samples obtained from patients with lumbar disc herniation. Thromboxane AィイD22ィエD2 (TXAィイD22ィエD2) synthase inhibitor, leukotriene BィイD24ィエD2 (LTBィイD24ィエD2) receptor antagonist and COX-2 inhibitor, which were injected into the epidural space, resulted in decrease of mechanical hyperalgesia 3 and 7 days after epidural injection. Inflammatory reactions and granulation tissue were less pronounced 7 days after the epidural injection. It is possible that TXAィイD22ィエD2 LTBィイD24ィエD2 and COX-2, which are produced in the inflammatory cells around the nerve root, play a significant role in mechanical hyperalgesia induced by application of nucleus pulposus on the nerve root in the rat. Epidural injection of LTBィイD24ィエD2 receptor antagonist, TXAィイD22ィエD2 synthase inhibitor and/or COX-2 inhibitor may be therapeutically useful, and may attenuate painful radiculopathy due to lumbar disc herniation. Less