Changes of the pulmonary arterial endothelium and smooth muscle function according to the recovery of the liver function

肺动脉内皮和平滑肌功能随肝功能恢复的变化

• 批准号: 10671395
• 负责人: HORIGUCHI Takashi
• 金额: $ 1.79万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671395/
• 关键词: Liver cirrhosis; Pulmonary artery; Endothelium; Smooth muscle; 血管・平滑筋; 肺硬変; 肺移植

Both carbon tetrachloride (CC14) and thioacetamide-induced cirrhotic rats did not cause pulmonary hypertension. These results were different from previous report.We compared the pulmonary vascular reactivity of isolated pulmonary arteries (PA) from control, and rats with cirrhotic rats induced by CC14. The responses of PA rings to cumulative concentrations of acetylcholine (Ach) and sodium nitroprusside (SNP) were studied. The contractile response to pheylephrine was significantly reduced in cirrhotic PA rings as compared with control. There was no difference in the relaxation of PA rings in response to Ach. Relaxation of PA rings in response to SNP was significantly increased in cirrhotic PA ringS as compared with control.After protamine reversal of heparin in cirrhotic rats increase in PA pressure and decrease in systemic arterial pressure were significantly greater than in control rats.

四氯化碳（CC14）和硫代乙酰胺诱导的哮喘大鼠没有引起肺动脉高压。本实验比较了正常大鼠和CC14致肺动脉炎大鼠的离体肺动脉反应性。研究了PA环对乙酰胆碱（Ach）和硝普钠（SNP）累积浓度的反应。与对照组相比，缺血性PA环对苯丙氨酸的收缩反应显著降低。PA环对Ach的舒张反应无差异。与对照组相比，SNP可使缺血大鼠PA环的舒张反应明显增强，肝素鱼精蛋白逆转后，缺血大鼠PA压力的升高和体循环动脉压的降低均明显大于对照组。