Changes of the pulmonary arterial endothelium and smooth muscle function according to the recovery of the liver function

四氯化碳(CC14)和硫代乙酰胺诱导的肝硬变大鼠均不引起肺动脉高压。这些结果与以前的报道不同。我们比较了对照组大鼠和CC14诱导的肝硬变大鼠的肺血管反应性。本文研究了PA环对乙酰胆碱(Ach)和硝普钠(SNP)累积浓度的反应。与对照组相比，肝硬变PA环对苯肾上腺素的收缩反应显著降低。PA环对Ach的松弛作用无明显差异。肝硬变PA环对SNP反应的PA环松弛明显高于对照组。肝素翻转鱼精蛋白后，肝硬变大鼠PA压升高和体动脉压降低的幅度明显大于对照组。

Both carbon tetrachloride (CC14) and thioacetamide-induced cirrhotic rats did not cause pulmonary hypertension. These results were different from previous report.We compared the pulmonary vascular reactivity of isolated pulmonary arteries (PA) from control, and rats with cirrhotic rats induced by CC14. The responses of PA rings to cumulative concentrations of acetylcholine (Ach) and sodium nitroprusside (SNP) were studied. The contractile response to pheylephrine was significantly reduced in cirrhotic PA rings as compared with control. There was no difference in the relaxation of PA rings in response to Ach. Relaxation of PA rings in response to SNP was significantly increased in cirrhotic PA ringS as compared with control.After protamine reversal of heparin in cirrhotic rats increase in PA pressure and decrease in systemic arterial pressure were significantly greater than in control rats.