Mechanisms of postoperative cognitive dysfunction after inhalation anesthesia

吸入麻醉剂残留的亚麻药浓度可能与术后精神运动和生理功能受损有关。我们测量了七氟醚在大鼠的血液和脑中以及人类的血液中的浓度，直到七氟醚停用一周。即使在停药7天后，大鼠的血液和脑中也含有七氟醚。麻醉后7天七氟醚在脑内的浓度约为血药浓度的6倍。即使在七氟醚麻醉后7天，人类的血液中也含有七氟醚。异丙酚麻醉2天后，血和脑组织中异丙酚消失。

Residual subanesthetic concentration of an inhaled anesthetic may be associated with postoperative impairment of psychomotor and physiologic function. We measured sevoflurane concentrations in blood and brain in rats and blood in humans until 1 week after discontinuation of sevoflurane. Blood and brain in rats contained sevoflurane even 7 days after discontinuation of the anesthetic. The concentrations of sevoflurane in brain 7 days after anesthesia were approximately 6 times their blood concentrations. Blood in humans also contained sevoflurane even 7 days after sevoflurane anesthesia. On the other hand, Propofol disappeared in both blood and brain 2 days after propofol anesthesia.