Spectral analysis of human autonomic nerve responses to vestibular stimulation

人类自主神经对前庭刺激反应的频谱分析

• 批准号: 10671598
• 负责人: INOKUCHI Akira
• 金额: $ 2.3万
• 依托单位: Saga Medical School (2000)Kyushu University (1998-1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671598/
• 关键词: vestibular autonomic response; spectrum analysis; autonomic nerve activity change; continuous BP measurement; 末梢血流量測定

Autonomic nerve dysfunction has been thought to be one of the etiological causes of vertigo and it is suggested that the symptoms such as nausea, cold sweating or palpitation are due to abnormal increment in vestibular-autonomic reflex. However, its detail is unclear. Recent works concerning the spectral analysis of R-R interval on ECG demonstrated that evaluation of α and β sympathetic and parasympathetic nerve activities can be possible. In the present study, the response of autonomic nervous activity was measured when various vestibular stimulations are applied.(1) on vertical rotation : α sympathetic nerve activities were not changed during and after 500 seconds stimulation with angular acceleration of 29 degrees/sec at 0.1Hz at all. Stimulation with angular acceleration of 57 degrees/sec at 0.2Hz produced 60 min increase starting 7 min after the end of stimulation. Conversely, decrease of activity was seen during stimulation with angular acceleration of 114 degrees/sec at 0.4Hz. T … More his decrease disappeared just after the stimulation ended. Similar activity change was observed on β sympathetic nerve activities at stimulation of 0.2Hz, but at stimulations of 0.1Hz and 0.4Hz, there was no significant change. Changes on parasympathetic nerve component were mirror-image of α sympathetic nerve one's ; it decreased for 60 min 7 min after the end of stimulation at 0.2 Hz. Patients with vertigo did not showed significant decrease in β sympathetic and parasympathetic nerve activities after 0.2Hz stimulation.(2) off vertical stimulation : increase in a sympathetic nerve activities and decrease in parasympathetic nerve activities became more evident. Caloric stimulation (20℃ water) suppressed the α sympathetic nerve activities for several min but no change was seen on β sympathetic and parasympathetic nerve activities. The present study revealed that spectral analysis is useful in detecting the activity changes during vestibular stimulations and in evaluating the dizzy patients. Less

自主神经功能障碍被认为是眩晕的病因之一，并认为恶心、冷汗或心悸等症状是由于前庭自主神经反射异常增加所致。然而，其细节尚不清楚。最近关于心电图R-R间期的频谱分析的工作表明，α和β的交感和副交感神经活动的评估是可能的。在本研究中，我们测量了不同的前庭刺激对自主神经活动的影响：(1)垂直旋转：在0.1赫兹，以29度/秒的角加速度刺激500秒后，α交感神经活动没有改变。以0.2Hz57度/秒的角加速度刺激，从刺激结束后7min开始增加60min。反之，在0.4赫兹的角加速度为114度/秒的刺激下，活动减少。T…更重要的是，刺激结束后，他的减少就消失了。在0.2 Hz刺激时，β交感神经活动也有类似的活动变化，而在0.1 Hz和0.4 Hz刺激时，则无明显变化。副交感神经成分的变化与α交感神经成分的变化类似，在0.2 Hz刺激结束后7min，副交感神经成分减少60min。眩晕患者经0.2 Hz刺激后，β交感神经和副交感神经活动无明显下降。(2)非垂直刺激：交感神经活动增加，副交感神经活动减少更为明显。热刺激(20℃水)可抑制α交感神经活动数分钟，但对β交感神经和副交感神经活动无明显影响。本研究表明，频谱分析在检测前庭刺激时的活动变化和评估眩晕患者方面是有用的。较少

项目成果

Yasuda T,Nakagawa T,Inoue H,Iwamoto M,Inokuchi A: "The role of the labyrinth, proprioception and plantar mechanosensors in the maintenance of an upright posture."Eur Arch Otorhinolaryngol. 256. S27-S32 (1999)

Yasuda T、Nakakawa T、Inoue H、Iwamoto M、Inokuchi A：“迷宫、本体感觉和足底机械传感器在维持直立姿势中的作用。”Eur Arch Otorhinolaryngol。

横光智,嬉野元喜,井之口昭,小宮山荘太郎: "カロリック刺激による血圧および末梢血流の変動"頭頸部自律神経. 12. 36-41 (1998)

Satoshi Yokomitsu、Motoki Ureshino、Akira Inoguchi 和 Sotaro Komiyama：“热量刺激引起的血压和外周血流量的变化”头颈自主神经系统。

田中剛,佐藤慎太郎,鈴木久美子,溝上宏幸,井之口昭: "当科における聴神経腫瘍症例の神経耳科学的所見の検討"耳鼻と臨床. 46・5. 381-384 (2000)

Tsuyoshi Tanaka、Shintaro Sato、Kumiko Suzuki、Hiroyuki Mizokami、Akira Inoguchi：“我科听神经瘤病例的神经耳科检查结果”《耳鼻喉科和临床科学》46・5（2000）。

Yasuda T, Makagawa T, Inoue H, Iwamoto M, Inokuchi A: "The role of the labyrinth, proprioception and plantar mechanosensors in the maintenance of an upright posture."Eur Arch Otorhinolaryngol. 256. S27-S32 (1999)

Yasuda T、Makakawa T、Inoue H、Iwamoto M、Inokuchi A：“迷宫、本体感觉和足底机械传感器在维持直立姿势中的作用。”Eur Arch Otorhinolaryngol。

Yasuda T, Nakagawa T, Inoue H, Iwamoto M, Inokuchi A: "The role of the labyrinth, proprioception and plantar mechanosensors in the maintenance of an upright posture."Eur Arch Otorhinolaryngol. 256. S27-S32 (1999)

Yasuda T、Nakakawa T、Inoue H、Iwamoto M、Inokuchi A：“迷宫、本体感觉和足底机械传感器在维持直立姿势中的作用。”Eur Arch Otorhinolaryngol。