Spectral analysis of human autonomic nerve responses to vestibular stimulation

植物神经功能障碍被认为是眩晕的病因之一，眩晕的恶心、出冷汗、心悸等症状可能是前庭-植物神经反射异常增强所致。然而，其细节尚不清楚。近年来，对心电图R-R间期的频谱分析表明，α和β交感神经和副交感神经活动的评估是可能的。在本研究中，自主神经活动的反应时，各种前庭刺激的应用进行了测量。(1)垂直旋转：在0.1Hz角加速度为29度/秒刺激500秒期间和之后，α交感神经活动完全没有改变。在0.2Hz下以57度/秒的角加速度进行刺激，在刺激结束后7分钟开始产生60分钟的增加。相反，在以0.4Hz的114度/秒的角加速度刺激期间观察到活动减少。不 关于我们 刺激结束后他的下降消失了。在0.2Hz刺激时，β交感神经活动也有类似的变化，而在0.1Hz和0.4Hz刺激时，β交感神经活动无明显变化。副交感神经成分的变化与α交感神经成分的变化呈镜像关系，在0.2Hz刺激结束后7 min，副交感神经成分减少，持续时间为60 min。眩晕患者在0.2Hz刺激后β交感神经和副交感神经活动无明显降低。(2)非垂直刺激：交感神经活动的增加和副交感神经活动的减少变得更加明显。热刺激（20℃水）抑制α交感神经活动数min，但对β交感神经和副交感神经活动无明显影响。本研究显示，频谱分析在检测前庭刺激时的活动变化和评估眩晕患者方面是有用的。少

Autonomic nerve dysfunction has been thought to be one of the etiological causes of vertigo and it is suggested that the symptoms such as nausea, cold sweating or palpitation are due to abnormal increment in vestibular-autonomic reflex. However, its detail is unclear. Recent works concerning the spectral analysis of R-R interval on ECG demonstrated that evaluation of α and β sympathetic and parasympathetic nerve activities can be possible. In the present study, the response of autonomic nervous activity was measured when various vestibular stimulations are applied.(1) on vertical rotation : α sympathetic nerve activities were not changed during and after 500 seconds stimulation with angular acceleration of 29 degrees/sec at 0.1Hz at all. Stimulation with angular acceleration of 57 degrees/sec at 0.2Hz produced 60 min increase starting 7 min after the end of stimulation. Conversely, decrease of activity was seen during stimulation with angular acceleration of 114 degrees/sec at 0.4Hz. T … More his decrease disappeared just after the stimulation ended. Similar activity change was observed on β sympathetic nerve activities at stimulation of 0.2Hz, but at stimulations of 0.1Hz and 0.4Hz, there was no significant change. Changes on parasympathetic nerve component were mirror-image of α sympathetic nerve one's ; it decreased for 60 min 7 min after the end of stimulation at 0.2 Hz. Patients with vertigo did not showed significant decrease in β sympathetic and parasympathetic nerve activities after 0.2Hz stimulation.(2) off vertical stimulation : increase in a sympathetic nerve activities and decrease in parasympathetic nerve activities became more evident. Caloric stimulation (20℃ water) suppressed the α sympathetic nerve activities for several min but no change was seen on β sympathetic and parasympathetic nerve activities. The present study revealed that spectral analysis is useful in detecting the activity changes during vestibular stimulations and in evaluating the dizzy patients. Less