A study on the influences of changes of regional tissue blood flow volume on energy metabolism in masticatory muscles
局部组织血流量变化对咀嚼肌能量代谢影响的研究
基本信息
- 批准号:10671811
- 负责人:
- 金额:$ 1.98万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to clarify the influences of chronic decrease in blood flow volume on energy metabolism in masticatory muscles, we tried to establish the method for obtaining 31P-spectra by using NMR, and tried to make the the wister rat model in which the blood flow volume of the gastrocneminus muscles and the soleus muscles chronically continued to decrease with bound dominant artery. As the parameters of regional tissue blood flow volume, oxygen saturation level of blood (StO2) and total hemoglobin (Hb) volume were measured using a three wavelength spectrophotometric method.The results were as follows;1. Using a 7T NMR and a surface coil (25mm diameter), we obtained the 31P-spectra of ATP sample, and we were able to detect peaks of α, β, γ-ATP. However, the 31P-spectra of rat muscles were not obtained clearly because of noise from surrounding tissues. This problem is expected to be solved by improvement in program of control system of the NMR.2. We obtained precise reproduciblity in measurement of StO2 and Hb volume, when we fixed both the probe of measuring apparatus and the leg of rats using devices which we made for fixation appropriately.3. Just after binding of the artery, the value of StO2 and total Hb volume declined by about 30% and 70%, respectively. These levels continued one or two months after binding. Therefore, it was suggested that we could make the relatively chronic model in which the blood flow volume of the gastrocneminus muscle and the soleus muscles decreased obviously.
为了阐明咀嚼肌血流量慢性减少对能量代谢的影响,我们尝试建立了利用核磁共振(NMR)获得31 P谱的方法,并尝试制作了优势动脉束缚下腓肠肌和比目鱼肌血流量慢性持续减少的wister大鼠模型。采用三波长分光光度法测定血氧饱和度(StO 2)和总血红蛋白(Hb),作为局部组织血流量的参数。用~ 7 TNMR和表面线圈(直径25 mm)获得了ATP样品的~(31)P谱,并能检测到α,β,γ-ATP峰。然而,由于周围组织的噪声,大鼠肌肉的31 P光谱不能清楚地获得。这一问题有望通过改进核磁共振仪控制系统的程序来解决。通过自制的固定装置将测量仪的探头与大鼠的腿固定,使StO 2和Hb体积的测量具有精确的重复性.动脉结扎后即刻,StO 2和总Hb量分别下降约30%和70%。这些水平在结合后持续了一个或两个月。因此,我们可以制作腓肠肌和比目鱼肌血流量明显减少的相对慢性模型。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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YAMAGUCHI Taihiko其他文献
YAMAGUCHI Taihiko的其他文献
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08672222 - 财政年份:1996
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06671939 - 财政年份:1994
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$ 1.98万 - 项目类别:
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