Successive changes in bone and vasculature surrounding dental implants under different mastication-functional conditions

不同咀嚼功能条件下牙种植体周围骨和脉管系统的连续变化

• 批准号: 10671853
• 负责人: SUWA Fumihiko
• 金额: $ 1.47万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671853/
• 关键词: Dental implant; Microvascularization; Osteogenesis; Repairing of wound; SEM; Monkey; Plastic injection; Repairing of wound

The purpose of this study was to investigate successive bone and vasculature changes surrounding dental implants that used metal or acrylic crown superstructure, and then compare the differences found.The Japanese monkeys having a similar occlusal pattern to humans were used in this study. Implants coated with anode oxidized titanium were implanted in the mandible molar area. After implanting, the animals were kept for 12 weeks before mounting metal or acrylic crowns, but one of them was killed after 12 weeks. Experimental animals mounted the crowns were killed after 1,4,8,12,20 weeks respectively. Using acrylic resin mocrovasculature corrosion injection method, the specimens of microvasculature cast and bone surrounding the implants were formed, and then three-dimensionally observed using scanning electron microscopy to note the successive changes in both types of tissues.Our results can be summarised as follows.1) With both metal and acrylic crowns, initiation of the vigorous bone-growth stage began approximately 4 weeks after crown mounting, and the implant body became sufficiently fixed after 8 weeks.2) When metal crowns were used, the thickness of the implantal alveolar bone surrounding the implant increased. However, with acrylic crowns, the thickness of the bone increased only slightly.With both metal and acrylic crowns, abundant blood vessels were observed in the bone marrow space of the sponge bone surrounding the implant 4 weeks after mounting. However, as time progressed the bone marrow space became smaller and the amount of blood vessels also decreased.

本研究的目的是调查连续的骨和血管的变化，周围的牙种植体使用金属或丙烯酸冠上部结构，然后比较发现的差异。日本猴子具有类似的咬合模式，以人类在这项研究中使用。将阳极氧化钛涂层种植体植入下颌磨牙区。种植后，动物保持12周，然后安装金属或丙烯酸冠，但其中一个12周后被杀。分别于术后1、4、8、12、20周处死动物。采用丙烯酸树脂微血管腐蚀注射法，制作种植体周围骨组织和微血管铸型标本，扫描电镜观察种植体周围骨组织和微血管铸型的动态变化，结果表明：1）金属冠和丙烯酸树脂冠均在种植后4周左右开始骨生长旺盛期; 2）金属全冠修复后，种植体周围牙槽骨厚度增加，种植体周围牙槽骨厚度增加。然而，丙烯酸树脂冠，骨的厚度仅略有增加。无论是金属和丙烯酸树脂冠，在安装后4周，在种植体周围的海绵骨的骨髓间隙中观察到丰富的血管。然而，随着时间的推移，骨髓空间变小，血管数量也减少。

项目成果

上田直克、川添堯彬、鳥居克典、松谷善雄、更谷啓治、諏訪文彦、戸田伊紀、池 宏海、竹村明道: "動揺度からみた咬合機能下における骨内インプラント周囲組織の評価"日本補綴歯科学会雑誌. 43・特別号. 145 (1999)

Naokatsu Ueda、Takaki Kawazoe、Katsunori Torii、Yoshio Matsutani、Keiji Saratani、Fumihiko Suwa、Iki Toda、Hiromi Ike、Akimichi Takemura：“从运动程度的角度评估咬合功能下骨内种植体周围的组织” 日本假肢杂志牙科协会。43/特刊145（1999）。

戸田伊紀、諏訪文彦、池 宏海、牧草一人 竹村明道、村岡正規、権田悦通: "抜歯窩治癒過程における実験的研究"歯科基礎医学会雑誌. 41・5. 466 (1999)

Iki Toda、Fumihiko Suwa、Hiromi Ike、Hitoshi Kusa、Akimichi Takemura、Masanori Muraoka、Etsumichi Gonda：“拔牙牙槽愈合过程的实验研究”日本基础牙科医学会杂志 41, 5. 466 (1999)。 ）

上田直克、川添堯彬、鳥居克典、松谷善雄、更谷啓治 諏訪文彦、戸田伊紀、池 宏海、竹村明道: "動揺度からみた咬合機能下における骨内インプラント周囲組織の評価"日本補綴歯科学会雑誌. 43・特別号. 145 (1999)

Naokatsu Ueda、Takaki Kawazoe、Katsunori Torii、Yoshio Matsutani、Keiji Saratani、Fumihiko Suwa、Iki Toda、Hiromi Ike、Akimichi Takemura：“从运动程度的角度评估咬合功能下骨内种植体周围的组织”日本修复学学术杂志。 43/特刊145（1999）

戸田伊紀、北山展弘、村岡正規、諏訪文彦、権田悦通、杉原富人: "吸収性コラーゲン材の抜歯窩への応用"歯科基礎医学会雑誌. 39・抄録集. 446 (1997)

Iki Toda、Nobuhiro Kitayama、Masanori Muraoka、Fumihiko Suwa、Etsumichi Gonda、Tomito Sugihara：“可吸收胶原材料在拔牙窝中的应用”日本基础牙科医学学会杂志 39，摘要 446。

諏訪文彦: "インプラントと骨周囲の再生―非機能下と機能下における微細血管構築と骨形成―"日本歯科医学会. 17・. 124-129 (1998)

Fumihiko Suwa：“种植体和骨膜再生 - 非功能性和功能性条件下的微血管构建和骨形成 -”日本牙科协会 17·124-129（1998）。