Analysis for Prostaglandin E2 and Vascular Endothelial Growth Factor in the Articular Disc and Synovial Cell in case of Internalderangement of the Temporomandibular Joint

在德国图宾根大学解剖研究所，我研究了翼侧肌路径的变化与关节盘畸形之间的关系，研究结果表明两者之间没有显著性。但在完全变形的关节盘中，在椎间盘的前下段发现高浓度的硫酸角蛋白和硫酸软骨素-6，并发现滑膜增生。在关节盘完全变形的临床内脱位病例中，滑膜增生中发现了Tenascin，椎间盘中也发现了Matrix Metaro蛋白酶-3，说明重构和繁殖同时发生。在这种情况下，Substance-P和COX-1分布在增生滑膜的血管附近，热休克蛋白47 （Heat-Schock Protein-47, HSP-47）的定位也特异于椎间盘的前-内段，但HSC-70在椎间盘的方向处被鉴定出来。我们还从内部紊乱的病例中建立了滑膜细胞系，在白细胞介素-1b （1ng/ml）的刺激下，细胞系自分泌血管

In Anatomy institute, Tubingen university Germany, I researched the relation between the variation of the path way on lateral-pterygoid muscle and deformity of the articulator-disc, as the result of this research, there was no significance between them. But in the completely deformed articulator disc, high concentration of keratan-sulfate and chondroitin-6 sulfate wereidentified in the antero-inferior part of the disc and hyperplastic synovial membrane was identified in these cases.In the completely deformed articulator disc of clicical internalderangement cases, Tenascin was recognized in the hyperplastic synovial membrane and Matrix Metaro Protease-3 also found in the disc, which means remodeling and reproduction were occurred in the same time. In such cases, Substance-P and COX-1 were distributed near the vascular vessels in the hyperplastic synovial membrane, and Localization of Heat-Schock Protein-47 (HSP-47) was also specific in the antero-inner part of the disc, but the HSC-70 was identified in roard bearing part of the disc. We also established the synovial cell line from internalderangement cases, with the stimulation of Inter-leukin-1b (1ng/ml), the cell line autocrined Vascular