STUDY ON THE ANIMAL CRUDE DRUGS, ESPECIALLY LIPID COMPOSITION.

动物源性药物特别是脂质成分的研究。

• 批准号: 10672013
• 负责人: NODA Naoki
• 金额: $ 2.11万
• 依托单位: SETSUNAN UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10672013/
• 关键词: earthworm; sea anemone; 1,2-cyclic acetal type sn-glycero-3-phosphoethanolamine; 1,4-benzodioxane; Cryptotympana sp.; cuticle; quinoline sulfate; centipede; イソギンチャク; 動物生薬; ベンゾダイオキシン類; イシワケイソギンチャク; プラズマローゲン; スフィンゴホスフォノリピド; サイクリックアセタール型グリセロホスフ

This study was undertaken to search for lead compounds of drug design from animal crude drugs.1. Four glycerophosphocholines together with four glycosphingolipids were isolated in pure state from the earthworm, Pheretima asiatica. Their structures were determined on the bases of chemical and spectral data.2. The total lipid fraction obtained from the sea anemone, Actiniogeton sp.was analyzed, and 1,2-cyclic acetal type sn-glycero-3-phosphoethanolamines were isolated. They were revealed to be so-called Feulgen's acetalphosphatides, which have been regarded as artifacts derived from original plasmalogens. We examined whether these compounds are intact constituents in the animal tissues, and obtained reliable confirmation that they are normally present in the sea anemone.3. Six optically active N-acetyldopamine dimers having 1,4-benzodioxane skeleton were obtained from cast-off shell of the Cicada, Cryptotympana sp. Their structures including absolute configurations were determined on the bases of NMR and circular dichroism spectroscopic data.4. Two quinoline sulfates were isolated from the centipede, Scolopendra subspinipes multidens L.Koch, and their structures were characterized.Novel compounds isolated in this study are expected to have unique biological activities, their activities will be examined.

本研究旨在从动物源性原料药中寻找药物设计的先导化合物.从亚洲环毛蚓（Pheretima asiatica）中分离得到四种甘油磷酸胆碱和四种鞘糖脂。根据化学和光谱数据确定了它们的结构.对海葵（Actiniogeton sp.）的总脂质部分进行了分析，并分离出1，2-环乙缩醛型SN-甘油基-3-磷酸乙醇胺。它们被发现是所谓的Feulgen乙酰磷脂，被认为是来自原始缩醛磷脂的人工制品。我们检测了这些化合物是否是动物组织中的完整成分，并获得了它们通常存在于海葵中的可靠证实。从蝉壳中分离得到6个具有1，4-苯并二氧六环骨架的光学活性N-乙酰多巴胺二聚体，通过核磁共振和圆二色谱数据确定了它们的结构和绝对构型.从蜈蚣（Scolopendra subspinipes multidens L.Koch）中分离得到两个喹啉硫酸酯化合物，并对其结构进行了表征。

项目成果

Ryuichiro Tanaka, Hiroaki Ishizaki, Takahiro Morita, Kazumoto Miyahara, Naoki Noda: "Evidence for the Presence of 1,2-Cyclic Acetal Type sn-Glycero-3-phosphocholines in the Sea Anemone, Actiniogeton sp."Lipids.. 35. 665-671 (2000)

Ryuichiro Tanaka、Hiroaki Ishizaki、Takahiro Morita、Kazumoto Miyahara、Naoki Noda：“海葵、Actiniogeton sp 中存在 1,2-环缩醛型 sn-Glycero-3-磷酸胆碱的证据。”脂质.. 35. 665

野田直規 他: "Optically Active N-Acetyldopamine Dimer of the Crudo.Drug "Zentai," the Cast-nff Shell of the Cicada, Cryptotympana sp."Chemical & Pharmaceutical Bulletin. 48. 1749-1752 (2000)

Naoki Noda 等人：“Crudo 的光学活性 N-乙酰多胺二聚体。药物“Zentai”，蝉的 Cast-nff 壳，Cryptotympana sp.”《化学与制药公报》48。1749-1752 (2000)。

田中龍一郎 他: "Evidence for the presence of 1, 2-Cyclic Acetal Type sn-Glycera-3-phosphoethanolamines in the Sea Anemane Actiniageton sp."Lipids. 35. 665-671 (2000)

Ryuichiro Tanaka 等人：“Sea Anemane Actiniageton sp. 中存在 1, 2-环缩醛型 sn-Glycera-3-磷酸乙醇胺的证据 35. 665-671 (2000)”

Naoki Noda, Shinichi Kubota, Yoko Miyata, Kazumoto Miyahara: "Optically Active N-Acetyl-dopamine Dimer of the Crude Drug "Zentai, " the Cast-off Shell of the Cicada, Cryptotympana sp."Chem.Pharm.Bull.. 48. 1749-1752 (2000)

Naoki Noda、Shinichi Kubota、Yoko Miyata、Kazumoto Miyahara：“生药“Zentai”的光学活性 N-乙酰基多巴胺二聚体，蝉的废弃外壳，Cryptotympana sp.”Chem.Pharm.Bull.. 48