Physiological determinants of pulmonary oxygen uptake kinetics to heavy exercise in humans

人类剧烈运动肺吸氧动力学的生理决定因素

• 批准号: 10680048
• 负责人: FUKUDA Yoshiyuki
• 金额: $ 1.79万
• 依托单位: Hiroshima Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680048/
• 关键词: oxygen uptake; heavy exercise; exercise physiology; 筋血流; 酸素運搬; ウォーシングアップ

Prior heavy exercise which induces lactic acidosis speeds pulmonary oxygen uptake (VOィイD22ィエD2) kinetics at the onset of following heavy exercise. The improved perfusion to the muscular sites is postulated as a mechanism to induce a more rapid VOィイD22ィエD2 response. Therefore, we first investigated the effects of delayed vagal withdrawal to the central circulation induced by the cold facial stimulation (CFS) and improved perfusion induced by the reactive hyperemia to working muscular sites on the VOィイD22ィエD2-kinetics during heavy cycling exercise. In the control protocol, VOィイD22ィエD2-kinetics for the 2nd heavy exercise bout were faster than that for the 1st bout, and VOィイD22ィエD2 slow component was also reduced. Whereas heat rates during CFS were consistently lower than those in a control protocol, no significant change was noticed in VOィイD22ィエD2-kinetics. The elevated muscle perfusion by reactive hyperemia also did not induce a more rapid VOィイD22ィエD2-kinetics. These results indicate that VOィイD22ィエD2 speeding phenomenon may not be associated with the improved perfusion to the working muscles. In these manipulations, however, we could not measured the blood flow response during exercise due to the motion of the exercising limbs. Therefore, we selected, as a next step, the knee extension exercise instead of cycling, because the femoral artery blood flow could be monitored continuously during the exercise, and investigated temporal associations between pulmonary VOィイD22ィエD2 and blood flow simultaneously during the repeated bouts knee-extension heavy exercise. Whereas VOィイD22ィエD2-kinetics during 2nd bout exercise speeded and the VOィイD22ィエD2 slow component reduced, there was no associated changes of femoral artery blood flow to the VOィイD22ィエD2. It was concluded that the speeding VOィイD22ィエD2-kinetics during heavy exercise by a prior heavy exercise might be derived from the factor(s) which is located in more close sites to the working muscles including the inside of muscles.

先前的剧烈运动会导致乳酸酸中毒，在剧烈运动开始时会加速肺氧摄取（VO_（22）D_2）动力学。肌肉部位灌注的改善被假定为诱导更快速的VO β D22受体D2反应的机制。因此，我们首先研究了冷面部刺激（CFS）引起的延迟迷走神经撤回到中央循环和改善工作肌肉部位反应性充血引起的灌注对重循环运动期间VO_（22）D_2-动力学的影响。在对照组中，第2次大负荷运动的VO_（22）V_（2尽管CFS期间的热速率始终低于对照方案中的热速率，但未观察到VO β D22 β D2-动力学的显著变化。由反应性充血引起的肌肉灌注升高也没有诱导更快的VO β D22-D2-动力学。这些结果表明VO_（22）O然而，在这些操作中，由于运动肢体的运动，我们无法测量运动期间的血流反应。因此，我们选择，作为下一步，膝关节伸展运动，而不是骑自行车，因为股动脉血流可以在运动过程中连续监测，并研究了肺VO D22和血流之间的时间关联，同时在重复的膝关节伸展重型运动。尽管第二次运动期间VO_（22）V_2D_2-动力学加快，VO_（22）V_2D_2慢成分减少，但VO_（22）V_2D_2的股动脉血流没有相关变化。结果表明，大负荷运动时的VO_（22）_（22）_（22）_（22）-动力学可能是由位于包括肌肉内部在内的更靠近工作肌肉的部位的因素引起的。

项目成果

Fukuba Y., et al: "The effect of endurance training on blood lactate clearance rate after maximal exercise."J. Sports Sci. 17 (3). 239-248 (1999)

Fukuba Y. 等人：“耐力训练对最大运动后血乳酸清除率的影响”。

Fukuba, Y. et al.: "Effects of diathermic-warning of muscles n Vo2-kinetics during heavy exercise"Med. Sci, Sprts Exerc. 30(5). S189 (1998)

Fukuba, Y. 等人：“剧烈运动期间肌肉透热警告对 Vo2 动力学的影响”Med。

Y.Fukuba et al.: "The Vo_2 slow component during repeated bouts heary cycling exercise in humans" Medicine and Science in Sports and Exercise. 31・5(印刷中). (1999)

Y. Fukuba 等人：“人类重复进行有氧自行车运动时的 Vo_2 缓慢成分”，运​​动与运动中的医学与科学 31·5（出版中）。

Fukuba Y., et al: "The "fatigue threshold" : Its physiological significance for assigning the transition from heavy to severe exercise."In : Recent Advances in Physiological Anthropology, M. Sato, K. Tokura, S. Watanuki 'eds.), Kyushu Univ. Press, Fukuoka

Fukuba Y. 等人：““疲劳阈值”：其对于从剧烈运动到剧烈运动的过渡的生理意义。”载于：生理人类学的最新进展，M. Sato、K. Tokura、S. Watanuki 编辑。

Fukuba,Y.et al.: "A metabolic limit on the ability to make up for lost time in endurance events"J.Appl.Physirl.. 87・2. 853-861 (1999)

Fukuba, Y. 等：“弥补耐力赛事中损失时间的能力的代谢限制”J.Appl.Physirl.. 87・2 (1999)。