Physiological determinants of pulmonary oxygen uptake kinetics to heavy exercise in humans

Prior heavy exercise which induces lactic acidosis speeds pulmonary oxygen uptake （VOイD22エD2） kinetics at the onset of following heavy exercise。The improved perfusion to the muscular sites is postulated as a mechanism to induce a more rapid VOイイD22イエD2 response。因此，我们首先研究了由于冷面部刺激（CFS）而导致的中心循环诱导的影响，并通过反应性hyperemia对在VO D22上工作肌肉站点上工作的动力学D2-动力学在重型循环练习期间进行。在控制协议中，VOY-D22-动力学用于第二次重型运动的速度比第一次训练快，而VOY-D22-D2慢成分也被减少了。在CFS期间，任何热度都不稳定地低于控制协议中的那些，在VO D22-动力学中没有明显的变化被注意到。由反应性hyperemia also did not induce一个更快速的VO D22-动力学的提升麝香灌注。These results indicate that VOイイD22エD2 speeding phenomenon may not be associated with the improved perfusion to the working muscles。在这些操纵中，无论如何，我们无法衡量血液流动的反应在练习期间到练习肢体的运动。因此，我们选择了下一个步骤，即膝关节延长运动中的循环，因为女性电池的血液流动可以在锻炼期间持续监测，以及在脉搏性VO之间进行调查的临时协会D22和血液流动同时在重复的靴子膝盖-重型锻炼期间监测。Whereas VO D22-动力学during 2nd bout exercise speeded and the VO D22-D2 slow component reduced， there is no associated changes of femoral artery blood flow to the VO D22-D2。它包括一个快速的VO D22-D2-动力学期间的重型运动可能是由一个前重型运动衍生出来的因素（s），它位于更近的网站上，包括在室内的工作Muscles。

Prior heavy exercise which induces lactic acidosis speeds pulmonary oxygen uptake (VOィイD22ィエD2) kinetics at the onset of following heavy exercise. The improved perfusion to the muscular sites is postulated as a mechanism to induce a more rapid VOィイD22ィエD2 response. Therefore, we first investigated the effects of delayed vagal withdrawal to the central circulation induced by the cold facial stimulation (CFS) and improved perfusion induced by the reactive hyperemia to working muscular sites on the VOィイD22ィエD2-kinetics during heavy cycling exercise. In the control protocol, VOィイD22ィエD2-kinetics for the 2nd heavy exercise bout were faster than that for the 1st bout, and VOィイD22ィエD2 slow component was also reduced. Whereas heat rates during CFS were consistently lower than those in a control protocol, no significant change was noticed in VOィイD22ィエD2-kinetics. The elevated muscle perfusion by reactive hyperemia also did not induce a more rapid VOィイD22ィエD2-kinetics. These results indicate that VOィイD22ィエD2 speeding phenomenon may not be associated with the improved perfusion to the working muscles. In these manipulations, however, we could not measured the blood flow response during exercise due to the motion of the exercising limbs. Therefore, we selected, as a next step, the knee extension exercise instead of cycling, because the femoral artery blood flow could be monitored continuously during the exercise, and investigated temporal associations between pulmonary VOィイD22ィエD2 and blood flow simultaneously during the repeated bouts knee-extension heavy exercise. Whereas VOィイD22ィエD2-kinetics during 2nd bout exercise speeded and the VOィイD22ィエD2 slow component reduced, there was no associated changes of femoral artery blood flow to the VOィイD22ィエD2. It was concluded that the speeding VOィイD22ィエD2-kinetics during heavy exercise by a prior heavy exercise might be derived from the factor(s) which is located in more close sites to the working muscles including the inside of muscles.