TECHNIQUE FOR DETERMINATION OF CARDIAC OUTPUT DURING HEAVY EXERCISE

剧烈运动期间心输出量的测定技术

• 批准号: 6264951
• 负责人: BRUCE E. JOHNSON
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264951
• 关键词: Fick method; cardiac output; clinical research; diagnosis design /evaluation; exercise; heart disorder diagnosis; human subject; technology /technique

Over the last year, we have started the invasive studies comparing the newly developed open circuit technique to the direct Fick method. During 1998, we performed 4 of these studies during rest through various intensities of exercise, including maximal exercise. The preliminary results of the study have resulted in an abstract submission to the American College of Sports Medicine. Despite the invasive nature of the studies, there have been no problems. Our plans are to test 2 additional subjects, likely completing the studies during the winter and spring of 1999. The results of the study are quite promising and will likely contribute significantly to the non-invasive techniques currently used in the GCRC and may provide additional preliminary data for a subsequent grant submission concerning ventilation and perfusion matching during exercise. Several subjects recruited for the study did not complete all of the sessions for several reasons. These included 1 subject due to pregnancy, 1 due to a recently diagnosed medical concern, 1 subject due to leaving the clinic to perform medical rotations at Scottsdale and 1 subject preferred not to perform the invasive study. Each subject performs an initial maximal exercise test, a test to compare two non-invasive cardiac output techniques and a final test comparing the open circuit technique to the Fick technique.

在过去的一年里，我们已经开始了侵入性研究，比较新开发的开路技术与直接Fick方法。 在1998年期间，我们进行了4个这些研究在休息期间通过不同强度的运动，包括最大的运动。 该研究的初步结果已提交给美国运动医学学院。 尽管这些研究具有侵入性，但没有出现任何问题。 我们的计划是测试另外两个科目，可能在1999年冬季和春季完成研究。 该研究的结果是非常有希望的，可能会大大有助于目前在GCRC中使用的非侵入性技术，并可能提供额外的初步数据，为随后的拨款提交有关运动期间的通气和灌注匹配。由于几个原因，为研究招募的几个受试者没有完成所有的课程。 其中包括1例受试者因妊娠、1例受试者因最近诊断的医学问题、1例受试者因离开诊所在斯科茨代尔进行医学轮换和1例受试者不愿进行侵入性研究。 每名受试者进行初始最大运动试验、比较两种无创心输出量技术的试验和比较开路技术与Fick技术的最终试验。