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Effect of docosahexaenoic acid on the senile dementia of dogs.

二十二碳六烯酸对犬老年痴呆的作用。

基本信息

批准号：
10839009
负责人：
HARADA Etsumori
金额：
$ 2.11万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10839009/
关键词：
Aged dog Dementia Docosahexaenoic acid Model animal Ibotenic acid Electric activities in brain Visual evoked potential Brainstem auditory evokedpotential イボテン酸脳の電気活動視覚誘発電位聴性脳幹誘発電位

项目摘要

This investigation was carried out to examine the characteristic changes in aged dogs, and the physiological role of docosahexaenoic acid to brain function in animal models.1.To investigate the diagnostic value of electroencephalography (EEG) in aged dogs with several degrees of clinical symptomatology, EEG power spectral analyses were carried out on eighteen dogs in aging from 11 to 18 years. The resting EEG in the moderate and severe cases had striking abnormalities such as accentuation of delta, decreasing of fast activities and asymmetries. Consistency was demonstrated between the clinical- and EEG-diagnosis in the aged dogs, showing decreased total powers.2.The effect of supplementation with docosahexaenoic acid (DHA) in (n-3) deficient rats on learning ability was also studied in a model of learning, active avoidance test, after wearing. Although the percentages of avoidance in the (n-3) deficient rats (saline group) were constantly 20% or less until the 3rd session, the percenta … More ge of avoidance in the DHA supplemented rats rapidly increased 53% following the first administration. These results suggest that chronic consumption of a (n-3) fatty acid deficient diet could modify the biosynthesis of catecholamine in the brain, and might induce the behavioral disturbances.3.To investigate the sleep-wake rhythm in aged dogs, a radio-telemetry measurements of behavior were carried out for 24h. The aged dogs displayed marked fragmentation and disruption of the sleep-wake cycle characterized by repeated awakenings, and exhibited reductions in paradoxical sleep (PS) time and the diurnal distribution of slow wave sleep (SWS). The sleep disruption was reflected in the greater number of episodes of each behavioral state. These results demonstrate the age-related changes in sleep-wake rhythm in the dogs, furthermore, it is suggested that the dog is a useful model for sleep disorders such as daytime drowsiness, difficulties in initiating and maintaining sleep and early morning awakening in older people. Less

本研究旨在探讨老年犬脑功能的特征性变化，以及二十二碳六烯酸对老年犬脑功能的生理作用。1.为探讨脑电图（EEG）对不同程度临床痴呆的诊断价值，对18只11 ~ 18岁的老年犬进行了EEG功率谱分析。中、重度病例的静息脑电有明显异常，如delta加重、快速活动减少和不对称。老年犬的临床诊断与脑电图诊断一致，表现为总功率下降。2.通过戴用后主动回避学习模型，研究了补充二十二碳六烯酸（DHA）对（n-3）缺陷大鼠学习能力的影响。尽管（n-3）缺陷大鼠（生理盐水组）的回避百分比在第3次治疗前一直为20%或更低，但在第3次治疗后， ...更多信息在第一次给药后，补充DHA的大鼠的回避率迅速增加了53%。这些结果提示，长期摄入（n-3）脂肪酸缺乏饲料可改变脑内儿茶酚胺的生物合成，并可能导致行为障碍。3.采用无线电遥测技术对老年犬进行了24 h的行为学研究。老年犬表现出明显的碎片和破坏的睡眠-觉醒周期的特点是反复觉醒，并表现出减少反常睡眠（PS）的时间和昼夜分布的慢波睡眠（SWS）。睡眠中断反映在每种行为状态的发作次数更多。这些结果证实了狗的睡眠-觉醒节律的年龄相关变化，此外，这表明狗是老年人睡眠障碍如白天嗜睡、难以启动和维持睡眠以及清晨觉醒的有用模型。少