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Effects of Dietary Fiber on Digestive/Absorption Function Assessed by the Ileum Contents Perfusion Method

回肠内容物灌注法评估膳食纤维对消化/吸收功能的影响

基本信息

批准号：
11307005
负责人：
FUKUDA Shinsaku
金额：
$ 24.63万
依托单位：
Hirosaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11307005/
关键词：
dietary fiber pectin cellulose resistant starch digestion and absorption breath hydrogen bacterial flora ^<13>C 難消化性澱粉小腸液潅流法小腸液灌流法大腸癌

项目摘要

In this study, the effects of dietary fiber on digestive/absorption function in human were studied using Ileum Contents Perfusion Method as follows. 1. Measured the values of dietary fiber (resistant starch and pectin) in the terminal ileum to evaluate the true values of these fibers as dietary fiber. 2. In order to evaluate the calorie ingestion by the fermentation in the large intestine, the exhaled gas after dietary fiber (resistant starch, pectin, lactulose and cellulose) ingestion were measured. 3. Effect of dietary fiber on absorption of exogenous neutral fat using breath test. As a result, the mean rate of 5g of pectin collected at the terminal ileum was calculated as 85.0±10.8%. However, the mean rate of 10g of resistant starch was calculated as 34.7±9.7%. Differences among individuals were 20% in both studies. Therefore, the values of pectin or resistant starch as dietary fiber were estimated at about 90% or 35%, respectively. As for fermentation of fiber in the large intestine, patterns of fermentation of dietary fiber were differences among individuals and types of dietary fiber. As for effects of fiber on absorption of neutral fat, a single administration of 5g of pectin did not inhibit the absorption of exogenous lipids. Therefore, in order to reduce the cholesterol and triglyceride levels of patients in a clinical setting, a much longer-term daily administration of 5g of pectin as a DF supplement is thus considered necessary. We can clarify the part of metabolism of dietary fiber and its effects on digestive/absorption function in human body, and we believe that our results stimulate the progress of dietary fiber research in the future.

在本研究中，使用如下所示的肠内容物灌注法来研究膳食纤维对人体消化/吸收功能的影响。1.测量回肠末端膳食纤维（抗性淀粉和果胶）的值，以评估这些纤维作为膳食纤维的真实价值。2.为了评估大肠发酵的热量摄入，测定了膳食纤维（抗性淀粉、果胶、乳果糖和纤维素）摄入后的呼出气体。3.呼吸试验法研究膳食纤维对外源性中性脂肪吸收的影响。结果，在回肠末端收集5g果胶的平均率计算为85.0± 10.8%。而每10 g抗性淀粉的平均得率为34.7± 9.7%。两项研究中个体差异均为20%。因此，果胶或抗性淀粉作为膳食纤维的价值分别估计为约90%或35%。纤维在大肠中的发酵方式因个体和膳食纤维种类的不同而不同。至于纤维对中性脂肪吸收的影响，单次服用5g果胶并不能抑制外源性脂质的吸收。因此，为了在临床环境中降低患者的胆固醇和甘油三酯水平，因此认为有必要长期每日施用5g果胶作为DF补充剂。本研究结果有助于阐明膳食纤维在人体内的代谢作用及其对消化吸收功能的影响，并对今后膳食纤维的研究起到一定的推动作用。