Validation of the cardiac-vascular reactivity index and analysis of mixing type of pressor response

心血管反应性指数的验证和升压反应混合型的分析

• 批准号: 11610082
• 负责人: TANAKA Gohichi
• 金额: $ 0.38万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11610082/
• 关键词: stress reactivity; cardiovascular reactivity type; blood pressure; cardiac output; peripheral vascular resistance; posture; sustained stress; 末梢血管トーヌス; 反応性充血; 指尖容積脈波; 皮膚血管抵抗

Two contrastive types has been differentiated for the cardiovascular stress reactivity, i.e., cardiac and vascular type. This study introduced new index of cardiac-vascular reactivity pattern (CVI) and examined whether CVI combined with blood pressure reactivity index (BPI) was effective for the analysis of stress reactivity. In experiment 1, temporal variations in CVI and BPI were examined during sustained mental arithmetic task (MA), in which shift in the pressor mechanism was expected from cardiac to vascular one. Anticipation of (4min), engaging in (10min) and recovery from (4min) MA were recorded from 44 male undergraduates. Based on CVI and BPI during 1st 3min of MA, 4 groups was identified, i.e., cardiac and vascular reactors with higher pressor responder (RC and RV, respectively), and those with lower pressor responder (NC and NV, respectively). Persistent vascular responses were seen in vascular reactors. Blood pressure responder heightened not only vascular resistance but also cardiac pre-ejection period reactivity. Blood pressure is considered to be affected mainly by α-adrenergic mediated vascular resistance and be influenced by generalized sympathetic nervous reactivity. In experiment 2, the stability and validity were examined between supine and standing positions, and between MA and mirror drawing tasks (MD). Hemodynamic and autonomic indices were measured from 38 male undergraduates. Although correlations of reactivity were not significant between supine and standing position, CVI showed mixing variations of other cardiac and vascular measures of response. In conclusion, CVI appears to be an integrated measure of cardiac and vascular components in stress response. The primary advantage of CVI is the independence of sample statistics, and the comparability with other study.

心血管应激反应性有两种不同的类型，即，心血管型。本研究引入了心血管反应性模式（CVI）的新指标，并探讨了CVI与血压反应性指数（BPI）结合是否是分析应激反应性的有效方法。在实验1中，在持续心算任务（MA），在升压机制的转变，预计从心脏到血管的时间变化的CVI和BPI进行了检查。对44名男大学生进行了MA的预期（4 min）、参与（10 min）和恢复（4 min）的记录。根据MA前3 min的CVI和BPI，将MA分为4组，即：高升压反应者（RC和RV）和低升压反应者（NC和NV）。在血管反应器中观察到持续的血管反应。血压反应者不仅血管阻力增加，而且心脏射血前期反应性也增加。认为血压主要受α-肾上腺素能介导的血管阻力的影响，并受全身交感神经反应性的影响。实验二考察了仰卧位和站立位之间以及MA任务和画镜任务之间的稳定性和效度。对38名男大学生进行了血流动力学和自主神经功能测定。虽然仰卧位和站立位之间的反应性相关性不显著，但CVI显示其他心脏和血管反应措施的混合变化。总之，CVI似乎是一个综合措施的心脏和血管成分的应激反应。CVI的主要优点是样本统计的独立性，以及与其他研究的可比性。

项目成果

田中豪一: "ストレス評価のパラダイム-心臓血管系指標,反応型と疾病の前駆症状.特集「心の働きを評価する実験パラダイム」"生理心理学と精神生理学. (印刷中).

Goichi Tanaka：“压力评估范式 - 心血管指标、反应类型和疾病的前驱症状。专题：‘评估思维运作的实验范式’”生理心理学和心理生理学（出版中）。

G.Tanaka: "Meaning of cardiovascular stress response in the study of aging."Symposium "Contribution of psychophysiology to aging study" Jpn J Physiol Psychol Psychophysiol. 17(2). 53-54 (1999)

G.Tanaka：“心血管应激反应在衰老研究中的意义。”研讨会“心理生理学对衰老研究的贡献”Jpn J Physiol Psychol Psychophysicalol。

田中豪一: "Aging研究における心血管系ストレス反応性の意義.シンポジウム「加齢研究への生理心理学の貢献」"生理心理学と精神生理学. 7(2). 53-54 (1999)

Goichi Tanaka：“心血管应激反应在衰老研究中的意义。研讨会“生理心理学对衰老研究的贡献””生理心理学和心理生理学 7(2) (1999)。

G.Tanaka: "Paradigm for the assessment of stress reaction : Relationship between cardiovascular reactivity types and early signs of cardiovascular disease."Jpn J Physiol Psychol Psychophysiol. (in press).

G.Tanaka：“应激反应评估范式：心血管反应类型与心血管疾病早期症状之间的关系。”Jpn J Physiol Psychol Psychophysicalol。