Amediating role of allostatic load between chronic psychosocial stress and the vascular health in healthy young men

这项横断面研究是一项为期5年的前瞻性队列研究的一部分，该研究考察了心理社会压力和慢性压力对健康年轻人心血管疾病早期征兆的影响。我们特别研究了心理社会因素和血管健康之间的联系是否可以用健康的年轻男性的平衡负荷来解释。控制年龄的部分相关性与手指动脉僵硬、炎症标志物以及累积的不平衡负荷指数(ALI)显著相关。此外，ALI与涉及不健康饮食习惯和体育锻炼的愤怒相关人格和生活方式因素显著相关。总而言之，年轻人的动脉僵硬似乎与血管前炎症有关，也与整体生理失调和不平衡负荷有关。这些联系将被饮食生活方式和心理社会压力所缓和。

The present cross-sectional study was one part of a 5-years prospective cohort study which examines the effects of psychosocial and chronic stress on the early signs of cardiovascular disease in healthy young people. We examined especially if the association between psychosocial factors and vascular health was explained by allostatic load in healthy young men. Partial correlations controlling for age were significant for finger arterial stiffness with inflammatory markers, as well as with a cumulative allostatic load index(ALI). In addition, ALI was significantly correlated with angerrelated personality and lifestyle factors involving unhealthy eating habits and physical exercise. In conclusion, arterial stiffness in young people seems to be associated with vascular pro-inflammation as well as with overall physiological dysregulation and allostatic load. These associations would be moderated by eating lifestyle and psychosocial stress.