Differentiation of the functional from the structural vascular tone using new elasticity indices of the linger artery and their psychophysiological application

使用林格动脉的新弹性指数区分功能性血管张力和结构性血管张力及其心理生理学应用

• 批准号: 14510102
• 负责人: TANAKA Gohichi
• 金额: $ 1.66万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14510102/
• 关键词: arterial elasticity; pressure-volume function; aging; mental stress; reactive hyperemia; flow-mediated dilation; endotherial function; near-infrared spectroscopy; 暗算

A near-infrared finger photoplethysmogram adopting a wavelength of 810nm provides for the pulsatile ac component(ΔI) superimposed on the transmitted dc components in a normal (I:tissue plus blood) and an ischemic circulatory state (I_t:tissue only). Simultaneous recording of linger blood pressure provides for the distending pulse(PP) and mean blood pressure(MBP). Based on the Lambert Beer's law, indices of the arterial compliance (CI;= ΔI/I/PP) is advocated for the linger vasculature. We introduced the exponential pressure-volume model(V=a-b×exp(-nP)) and examined the effects of functional and structural variations in the vascular tone on these parameters. Experiment 1:Twelve female subjects underwent immersions of the contralateral hand in water at two different temperatures(44℃,22℃). CI calculated at 9OmmHg(CI90) of linear regression between log CI and MBP decreased significantly during 22℃ condition. Experiment 2:The functional relationship to the transmural pressure for CI was examined using linger-occlusion during mental arithmetics in sixteen females and reactive hyperemia in five. Logarithmically transformed CI was linearly associated with the transmural pressure. Changes in parameter a were most consistent among three parameters of the exponential model. Experiment 3:Age-associated differences in parameter a,b, and n were examined during resting condition between 31 young students and 9 middle aged workers. In the middle aged subjects, the model fitness deteriorated and only the parameter n was lowered compared with the young student. Parameter n was significantly correlated with brachial-ankle pulse wave velocity(baPWV) as a measure of arterial stiffness. Flow-mediated dilation(FMD) during reactive hyperemia at the wrist radial artery was recorded by oxygenated hemoglobin using near-infrared spectroscopy. Peak time of FMD was delayed in the young group as compared with the middle aged group and negatively correlated with baPWV.

采用810 nm波长的近红外手指体积图提供了在正常(I：组织加血液)和缺血循环状态(I_t：仅组织)下叠加在传输的DC分量上的搏动性交流分量(ΔI)。同时记录滞留血压提供了扩张脉搏(PP)和平均血压(MBP)。根据Lambert-Beer定律，建议采用动脉顺应性指数(CI；=ΔI/I/PP)来评价Linger血管系统。我们引入了指数压力-体积模型(V=a-b×exp(-np))，并研究了血管张力的功能和结构变化对这些参数的影响。实验一：12名女性受试者在两种不同温度(44℃和22℃)的水中浸泡对侧手。在22℃条件下，对数CI与平均动脉压之间的线性回归计算的CI在90 OmmHg(CI 90)时显著降低。实验2：对16例女性患者和5例反应性充血患者进行心算时的逗留-闭塞实验，研究CI患者的跨壁压与脑梗塞的功能关系。经对数变换后的CI与跨壁压呈线性相关。在指数模型的三个参数中，参数a的变化最为一致。实验三：考察了31名青年学生和9名中年工人在休息状态下a、b、n参数的年龄差异。中年被试的模型适合度比青年学生差，只有参数n比青年学生低。参数n与衡量动脉僵硬的臂踝脉搏波速度(BaPWV)显著相关。用近红外光谱分析氧合血红蛋白记录反应性充血时腕尺动脉的血流介导性扩张(FMD)。青年组FMD峰值时间较中年组延迟，且与baPWV呈负相关。

项目成果

Tanaka, G.: "Relationship between the vascular reactivity during mental stress test and the early markers of cardiovascular disease : featuring the MRS monitoring into the flow-mediated dilation in radial artery."Shinryounaika. 8. 67-73 (2004)

Tanaka, G.：“精神压力测试期间血管反应性与心血管疾病早期标志物之间的关系：以 MRS 监测桡动脉血流介导的扩张为特色。”Shinryounaika。

Tanaka, G., Kawana, S., Sawada, Y., Yamakoshi, K.: "Normalized pulse volume and blood volume as separate indices of finger arterial and venous tone : Examination under proprofol"Japanese Psychological Research. 45(1). 50-59 (2003)

Tanaka, G.、Kawana, S.、Sawada, Y.、Yamakoshi, K.：“标准化脉搏量和血量作为手指动脉和静脉张力的单独指数：异丙酚下的检查”日本心理学研究。

Tanaka, G., Sawada, Y., Matsumura, K., Nagano, Y., Yamakoshi, K.: "Finger arterial compliance as determined by transmission of light during mental stress and reactive hyperaemia"European Journal of Applied Physiology. 87(6). 562-567 (2002)

Tanaka, G.、Sawada, Y.、Matsumura, K.、Nagano, Y.、Yamakoshi, K.：“通过精神压力和反应性充血期间的光传输确定的手指动脉顺应性”欧洲应用生理学杂志。

Tanaka, G., Sawada, Y.: "Examination of normalized pulse volume-blood volume relationship : toward a more valid estimation of the finger sympathetic tone"International Journal of Psychophysiology. 48(3). 293-306 (2003)

Tanaka, G., Sawada, Y.：“标准化脉搏量与血量关系的检查：对手指交感神经张力进行更有效的估计”《国际心理生理学杂志》。

Tanaka, G., Sawada, Y, Matsumura, K.: "Examination of normalized pulse volume-blood volume relationship : Toward a more valid estimation of the finger vascular tone."The 42th Annual Meeting, October 2-6, Washington, DC, USA. Psychophysiology(Society for P

Tanaka, G.、Sawada, Y、Matsumura, K.：“标准化脉搏量与血量关系的检查：对手指血管张力进行更有效的估计。”第 42 届年会，10 月 2-6 日，华盛顿特区