Substitution Reactions of Rhenium Complexes

1. 二氯乙氧基氧氧基（三苯基膦）铼(V) ([ReOCl_2（OEt)(PPh_3)_2]）的碱水解，以二氯乙氧基（三苯基膦）铼(V)为原料合成了Re(V)和Re（IV）配合物。将氢氧化钠水溶液加入含有[ReOCl_2(OEt)(PPh_3)_2]的氯仿溶液中，引发碱水解反应。用分光光度法测定了有机相中铼的浓度。根据表观速率常数与氢氧根离子浓度的关系，表观速率常数可表示为κ_<upp> = κ [OH]，其中κ为[ReOCl_2(OEt)(PPh_3)_2]碱水解的速率常数。由此确定速率常数κ为κ = 1.03 X 10^<-4> M^<-4>s^<-1>。（25℃，Ι= 1.0 m）多示踪剂溶液中稀土、稀土等必需微量元素的吸收与分布将含稀土和稀土的多示踪剂溶液从金靶中化学分离后口服给药。铼几乎完全被老鼠的身体吸收。但它在尿液中排泄得很快。因此，研究铼配合物在大鼠体内的取代反应非常困难。虽然其在体内的吸收率低于Re，但也观察到Tc的快速消除行为。当另一种含Tc的示踪溶液口服给锌缺乏小鼠时，Tc在锌缺乏小鼠中的吸收率低于对照（正常）小鼠。

1. The base hydrolysis of dichloroethoxyoxobis(triphenylphosphine)rhenium(V) ([ReOCl_2(OEt)(PPh_3)_2])Dichloroethoxyoxobis(triphenylphosphine)rhenium(V) has been used for the synthesis of Re(V) and Re(IV) complexes as a starting material. An aqueous solution of sodium hydroxide was added to a chloroform solution containing [ReOCl_2(OEt)(PPh_3)_2] to initiate the base hydrolysis reaction. The concentration of rhenium in the organic phase was determined spectrophotometrically. On the basis of the dependence of the apparent rate constant on the concentration of hydroxide ion, the apparent rate constant could be expressed as κ_<upp> = κ [OH], where κ is the rate constant for the base hydrolysis of [ReOCl_2(OEt)(PPh_3)_2]. Thus the rate constant κ was determined to be κ = 1.03 X 10^<-4> M^<-4>s^<-1>. (25 ℃, Ι= 1.0 M)2. Uptake and distribution of Re, Tc and other essential trace elements in multitracer solutionsA multitracer solution including Tc and Re, chemically separated from gold target, was orally administered to rats. Rhenium was almost completely absorbed into rats' bodies. But it excreted in urine rapidly. Therefore, it was too difficult to investigate the substitution reactions of rhenium complexes in rats' bodies. Rapid elimination behavior was also observed for Tc although its absorption rate into their bodies was less than that of Re. When another tracer solution including Tc was administered orally to Zn-deficient mice, the uptake rate of Tc into Zn-deficient mice was lower than that of control (normal) mice.