High-performance SPECT for dynamic brain imaging

用于动态脑成像的高性能 SPECT

• 批准号: 10718519
• 负责人: Hamid Sabet
• 金额: $ 63.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10718519
• 关键词: Alzheimer' s Disease; Arizona; Back; Biological Models; Brain; Brain imaging; Cardiac; Cells; Clinical; Collaborations; Collimator; Compensation; Complex; Computed Tomography Scanners; Creativeness; Data; Dedications; Dementia; Development; Dimensions; Dose; Epilepsy; Evaluation; Floods; Frequencies; Gamma Cameras; Geometry; Goals; Head; Human; Image; Isotopes; Lasers; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Mechanics; Modeling; Noise; Optics; Parkinson Disease; Patients; Performance; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Process; Property; REM Sleep Behavior Disorder; Research; Resolution; Semiconductors; Signal Transduction; Structure; System; Systems Integration; Technetium 99m; Technology; Thick; Tracer; Update; Vertebral column; Visualization; Work; attenuation; cancer imaging; clinical application; cost; density; design; detector; digital; fabrication; high resolution imaging; human imaging; human study; image reconstruction; imaging study; improved; mosaic pattern; novel; nuclear imaging; portability; prototype; screening; single photon emission computed tomography; targeted imaging; ultra high resolution

PROJECT SUMMARY/ABSTRACT: Brain Single Photon Emission Computed Tomography (SPECT) imaging has been of great importance for many clinical applications such as epilepsy, dementia, posttraumatic stress disorder, Alzheimer’s disease, Parkinson’s disease, and tumor imaging. The conventional dual-head gamma cameras (DHGCs) which have been the mainstay in nuclear imaging (specifically for cardiac screening) are not optimized for brain imaging where achieving simultaneously high resolution and high sensitivity is necessary. Depending on the collimator choice, DHGC resolution is 7-15 mm FWHM, which is not very useful to visualize fine structures of the human brain. There are several ongoing projects with the premise of improved scanner performance compared to the DHGC systems, however they are either focusing on using old detector technology and mainly improving the collimator geometry or focusing on very expensive (order of magnitude compared with the current designs) semiconductor technology which also leads to a complex system. With this application we seek to develop a portable SPECT scanner for dynamic brain imaging with ~4 mm FWHM resolution at the same sensitivity of the DHGC or 8x more sensitivity at 7 mm resolution. The backbone of the design is our enabling technology to fabricate high resolution detectors at practical cost. The proposed project will open new avenues for low dose brain SPECT imaging applications and enable longitudinal studies.

项目摘要/摘要： 脑单光子发射计算机断层扫描（SPECT）成像非常重要 许多临床应用，例如癫痫，痴呆，创伤后应激障碍，阿尔茨海默氏病， 帕金森氏病和肿瘤成像。传统的双头伽玛相机（DHGC）具有 核成像中的主要阶（专门用于心脏筛查）未针对大脑成像进行优化 必须同时实现高分辨率和高灵敏度。取决于准仪 选择，DHGC分辨率为7-15毫米FWHM，这对于可视化人类的精细结构不是很有用 脑。与扫描仪性能提高的前提相比，有几个正在进行的项目 DHGC系统，但是他们要么专注于使用旧探测器技术，并主要改善 准直仪的几何形状或专注于非常昂贵的（与当前设计相比） 半导体技术也导致复杂的系统。 使用此应用，我们试图开发一个可用于〜4 mm的动态大脑成像的便携式SPECT扫描仪 FWHM分辨率在DHGC的相同灵敏度或7毫米分辨率下更灵敏度。骨干 设计的是我们的技术可以以实际成本制造高分辨率探测器。提议 项目将为低剂量的脑幽灵成像应用开放新途径，并实现纵向研究。