Behavior of cobalt as the in vivo zinc substitute metal

将8周龄的ICR系雄性小鼠分为4组。一组喂饲缺锌饲料和超纯水1 ~ 3周。第2、3、4组分别饲喂对照日粮、富钴缺锌日粮和富铜缺锌日粮。锌缺乏小鼠胰腺锌含量的变化可能表明，锌缺乏小鼠各器官组织中存在着增加钴摄入的机制，钴的作用是干扰锌的流出。

Male mice of the ICR strain, 8-week old, were divided into four groups. One group was fed with Zn-deficient diet and ultra pure water for one or three weeks. The second, third, and fourth group were fed with control diet, Co-enriched Zn-deficient diet, and Cu-enriched Zn-deficient diet, respectively. The change of Znconcentration in pancreases might indicate that some kinds of mechanisms which enhance the intake of Co in all the organs and tissues of Zn-def. mice could be operated, and Co functions to disturb that Zn flows out.