Study on Fluid Dynamic Characteristics of Turbulent Blood Flow

湍流血流的流体动力学特性研究

• 批准号: 11650199
• 负责人: TSUKIYA Tomonori
• 金额: $ 1.41万
• 依托单位: Research Institute of National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650199/
• 关键词: Non-Newtonian Fluids; Blood; Plasma; Viscosity; Casson's Formula; Artificial Heart; Centrifugal Pump; Measurement of Flow Rate; 血球濃度; 機械的補助循環; 血液流; 非ニュートン流; 乱流摩擦抵抗; 動粘度

The pressure - flow rate relationship in the ventricular assist system consisting of an artificial heart is helpful in order to diagnose and detect abnormal condition of the system, or to develop indirect measurement system which saves sensors for pressure and flow rate of the device being used. For example, we have developed the indirect flow rate measurement system using the power consumption of the driving motor of the centrifugal blood pump. This relationship, however, is subject to the physical properties of blood as well as the configuration of the system. The physical properties of flowing blood, or rheology of blood, is essential for such aims, but reports on physical properties of flowing blood under turbulent state, which is often observed in the mechanical assisting devices like artificial hearts, has hardly been investigated. The pressure drop across the circular pipe of turbulent flow was measured and compared between goat blood and a Newtonian fluid. Goat blood demonstrat … More ed slight decrease in the pressure drop than the Newtonian fluid, and the magnitude of the decrease in pressure drop was independent of blood cell concentration. The indirect measurement of flow rate of a centrifugal blood pump using motor power consumption was attempted, in which the effect of viscosity change on the accuracy was investigated. The centrifugal blood pump developed in our research institute was installed between the left apex and the descending aorta making a left heart bypass. The flow rate measured by this method has demonstrated sufficient accuracy for practical use when the viscosity is known. The extent of errors fluctuated with the change of hematocrit after in the course of time after surgical operation. The errors could be corrected by measuring the viscosity of the blood to the practically acceptable range by calibration data obtained with Newtonian fluids. The difference in pressure drop in turbulence due to Non-Newtonian properties, which was observed in the turbulent pipe flow, was found to have negligible effects in this measurement method of flow rate for the practical use. Less

人工心脏心室辅助系统的压力-流量关系有助于诊断和检测系统的异常状态，或开发间接测量系统，省去所使用装置的压力和流量传感器。例如，我们开发了利用离心血泵驱动电机功耗的间接流量测量系统。然而，这种关系取决于血液的物理特性以及系统的配置。流动血液的物理性质，或血液的流变学，对这些目标是必不可少的，但在紊流状态下流动血液的物理性质的报道，这是经常观察到的机械辅助装置，如人工心脏，几乎没有研究。对山羊血和牛顿流体在紊流环管内的压降进行了测量和比较。与牛顿流体相比，山羊血的压降下降幅度更小，且压降下降的幅度与血细胞浓度无关。尝试用电机功率间接测量离心血泵的流量，考察了粘度变化对测量精度的影响。本研究所研制的离心血泵安装在左心尖与降主动脉之间，形成左心旁路。当粘度已知时，用这种方法测量的流量具有足够的精度，可用于实际应用。误差程度随手术后红细胞压积的变化而波动。根据牛顿流体标定数据，将血液粘度测量到实际可接受的范围内，可以对误差进行校正。在紊流管流中观察到的非牛顿性质引起的紊流压降差异，在实际应用中对该流量测量方法的影响可以忽略不计。少

项目成果

Tsukiya T, et al.: "Study on the Fluid Dynamic Characteristics of Turbulent Blood Flow"Proceedings of the JSME 11^<th> Bioengineering Conference. 99-03. 260-261 (1999)

Tsukiya T 等人：“湍流血流的流体动力学特性研究”JSME 第 11 届生物工程会议论文集。

築谷朋典 他5名: "血液流の流体工学的特性に関する研究"第11回バイオエンジニアリング講演会講演論文集. 99-03. 260-261 (1999)

Tomonori Tsukutani 等 5 人：“血流的流体力学特性研究”第 11 届生物工程会议记录 99-03（1999）。

Tsukiya T, et al.: "Performance of an Newly Developed Implantable Centrifugal Blood Pump"ASAIO Journal. (in press). (2001)

Tsukiya T 等人：“新开发的植入式离心血泵的性能”ASAIO 杂志。