Development of the Multistage Centrifugal Blood Pump for the Extended Use of Rotary Blood Pumps

多级离心式血泵的开发以扩展旋转式血泵的使用

• 批准号: 18360094
• 负责人: TSUKIYA Tomonori
• 金额: $ 3.9万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18360094/
• 关键词: Centrifugal Pump; Multistage Pump; CFD; Cardiopulmonary Bypass; Shear Stress; 血液ポンプ; 心肺補助循環装置; ボリュート

The present study deals with the development of a novel centrifugal pump which consists of the multistage impeller. The use of a multistage impeller leads to generation of high pressure without increasing the rotational speed of the motor. The direct advantage of this structure will be the decreased amount of the blood cell destruction(blood trauma) in the device.The first prototype was designed for the virtual working condition of the flow rate of 3.0 L/min and the pressure difference of 500 mmHg. The prototype employs the following design features to ensure generation of high pressure.1. the suction volute in the inlet passage2. the impeller profile for high pressure3. the double volute to minimize the radial thrust on the impellerThe first prototype demonstrated the sufficient pump performance. The CFD analysis of the internal flow field of the device has revealed the need for design improvement in terms of the blood cell destruction and thrombus formation in the device.1 addition of the front shroud to the impeller2 use of the wider gap in the tongue of the double volute casing3 use of the shrouded return vaneThe second prototype with the above improvements demonstrated a bit lower hydraulic performance due to the increase in the internal leakage flow associated with the design change to enhance the wash-out condition of the device. However, we succeeded in decreasing the maximum shear stress over the lethal value for blood cell destruction and in elimination of the stagnant area which possibly leads to the thrombus formation.

本研究涉及一个新型离心泵的开发，该泵由多阶段叶轮组成。多阶叶轮的使用会导致高压产生，而不会增加电动机的旋转速度。该结构的直接优势将是设备中血细胞破坏（血液创伤）的量减少。第一个原型是为3.0 L/min的虚拟工作条件设计的，而压力差为500 mmHg。该原型采用以下设计功能来确保产生高压1。入口通道中的吸力2。高压3。双重静电以最大程度地减少叶轮上的径向推力，这表明了足够的泵性能。对设备内部流动场的CFD分析表明，在设备中的血细胞破坏和血栓形成方面需要改进设计。增强设备的冲洗状况。但是，我们成功地减少了血细胞破坏的致命值和消除可能导致血栓形成的停滞区域的最大剪切应力。

项目成果

Development of the multistage centrifugal blood pump

多级离心血泵的研制

• 发表时间: 2008
• 作者: Tsukiya T;ey al
• 通讯作者: ey al

Development of the Multistage Centufugal Blood Pump

多级离心血泵的研制

• 发表时间: 2008
• 作者: Tsukiya T;Taenaka Y;Horiguchi H;Tsujimoto Y
• 通讯作者: Tsujimoto Y

人工肺用二段遠心型血液ポンプの開発

人工肺用两级离心血泵的研制

• 发表时间: 2008
• 作者: 武甕虎太郎;野本剛司;堀口祐憲;辻本良信;築谷朋典;妙中義之
• 通讯作者: 妙中義之

Development of the Two-stage Centrifugal Blood Pump for a Cardiopulmonary Support System

心肺支持系统两级离心血泵的研制

• 发表时间: 2008
• 作者: Takemika T;Nomoto T;Horiguchi H;Tsujimoto Y;Tsukiya T;Taenaka Y
• 通讯作者: Taenaka Y