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Formation and Control of Higher-order Functional Structures of Biomodel Polymers

生物模型聚合物高阶功能结构的形成和控制

基本信息

批准号：
11650909
负责人：
KUNUGI Shigeru
金额：
$ 2.3万
依托单位：
Kyoto Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The physicochemical properties of the phase-transition of so-called themoresponsive synthetic polymers have been widely studied. We have investigated the effects of pressure on their behavior and showed that the pressure effects were highly interactive with the effects of inert salts, and that these results can be generally explained in terms of hydration and dehydration processes. The apparent transition properties and light scattering behavior of these polymers upon a variation in pressure and temperature are common to a number of other water-soluble bio-related polymers, from elastin model peptide to the dilute solutions of hydroxypropyl cellulose(HPC).In this project, we investigated the effects of pressure on the phase behavior of elastin model peptide((VPGIG)_<40>), and thermoresponsive vinyl polymers in dilute aqueous solutions. We found that pressure strongly affects the dissolution temperature and the light-scattering properties in this concentration range, and that the pressure effects are strongly interactive with added inert salts.Commonly the transition temperature(Tt), as measured by apparent light scattering, increased with an increase in pressure at lower pressures, but decreased with increasing pressure above 100-150 MPa. At lower temperatures, the transition pressure(Pt)of some polymers increased slightly with increasing temperature, but decreased with at temperatures above 10-15 ℃, as a result they showed elliptic phase diagrams.Both the Tt and the Pt showed strong concentration dependence on inert salt ; the Tt and the Pt decreased with increasing concentrations of salting-out ions such as KCl and K_2SO_4, whereas the addition of salting-in ions such as KI or KSCN increased the Tt and Pt.Based on these results, a general explanation of the elliptic phase diagram in similar systems has been elucidated.

所谓的热响应合成聚合物的相变的物理化学性质已经被广泛研究。我们已经研究了压力对它们的行为的影响，并表明压力效应与惰性盐的效应高度相互作用，并且这些结果通常可以用水合和脱水过程来解释。在本项目中，我们研究了压力对弹性蛋白模型肽（（VPGIG）_）和温敏乙烯基聚合物在稀水溶液中相行为的影响。<40>我们发现，在此浓度范围内，压力对溶解温度和光散射性质有强烈的影响，而且压力效应与加入的惰性盐有强烈的交互作用，通常在较低压力下，转变温度（Tt）随压力的增加而增加，但在100 - 150 MPa以上，转变温度随压力的增加而降低。在较低温度下，某些聚合物的相变压力（Pt）随温度升高而略有增加，但在10-15 ℃以上则随温度升高而降低，因而它们呈椭圆形相图，Tt和Pt均对惰性盐有很强的浓度依赖性; Tt和Pt随盐析离子如KCl和K_2SO_4浓度的增加而降低，而盐溶离子如KI或KSCN的加入使Tt和Pt增加。基于这些结果，阐明了类似体系中椭圆相图的一般解释。