Formation of time memory for temperature stimuli in rats

大鼠温度刺激时间记忆的形成

基本信息

  • 批准号:
    11670059
  • 负责人:
  • 金额:
    $ 2.43万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1999
  • 资助国家:
    日本
  • 起止时间:
    1999 至 2001
  • 项目状态:
    已结题

项目摘要

After daily temperature stimulus for 4 〜 5 hours limited to a fixed time, time memory for temperature stimuli can be formed in the thermoregulatory system of rats and humans and, according to the memory, thermoregulatory functions alter during the period when subjects were previously exposed to heat without actual temperature stress. We investigated the Fos protein expression in various nuclei in the brain in rats after subjection to daily timed temperature stress. Rats, kept in a 12 : 12 LD cycle, were exposed to heat or cold only in the last half of the dark phase of the day. Control rats were not exposed to temperature stress. After a 12-day temperature exposure schedule, they were anesthetized and their brains were removed in the first half (M), at the middle (N) or in the last half of the dark phase (A) of a day. The brain samples were then sliced and immunohistochemical staining for Fos protein was performed. In the control and cold-exposed rats, the number of Fos-positive cells in the preoptic anterior hypothalamus increased during the periods N and A compared to that of the period M, while it did not increase in the period A in the heat-exposed rats. The number of Fos-positive cells in the suprachiasmatic nucleus did not change in the dark phase in the controls, whereas it gradually decreased in the dark phase in the heat- and cold-exposed rats. A similar pattern of Fos expression was seen in the paraventricular nucleus. There were no differences in the Fos expression in the supraoptic, supramammilary and lateral mammilary nuclei among the groups. It seems that timed daily temperature stimuli alter the pattern of day-night variations of neuronal activities in the several brain nuclei in rats.
大鼠和人的体温调节系统在每天固定时间内接受4 ~ 5小时的温度刺激后,可形成对温度刺激的时间记忆,根据这种记忆,在受试者先前暴露于热而没有实际温度应激的时期,体温调节功能发生改变。本研究观察了每日定时温度应激大鼠脑内不同核团Fos蛋白的表达。保持在12:12 LD循环中的大鼠仅在一天的黑暗阶段的后半部分暴露于热或冷。对照组大鼠不暴露于温度应激。在12天的温度暴露时间表后,将它们麻醉,并在一天的黑暗阶段的前半部分(M)、中间部分(N)或后半部分(A)取出它们的大脑。然后将脑样品切片并进行Fos蛋白的免疫组织化学染色。对照组和冷暴露组大鼠下丘脑视前区Fos阳性细胞数在N期和A期较M期增加,而热暴露组大鼠下丘脑视前区Fos阳性细胞数在A期没有增加。对照组大鼠视交叉上核内Fos阳性细胞数在暗期无明显变化,而冷热暴露组大鼠视交叉上核内Fos阳性细胞数在暗期逐渐减少。在室旁核也有类似的Fos表达。Fos在视上核、乳头上核和乳头外侧核的表达在各组间无差异。每日定时的温度刺激似乎改变了大鼠几个脑核团神经元活动的昼夜变化模式。

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Shido O, et al.: "Ambient temperature preferred by humans acclimated to heat given at a fixed daily time."Physiol.Behav.. (in press).
Shido O 等人:“适应每天固定时间加热的人类首选的环境温度。”Physiol.Behav..(正在出版)。
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
Sugimoto N., et al.: "Selected ambient temperatures of rats acclimated to heat given on various schedules"Pflugers Archiv. 438(6). 766-770 (1999)
Sugimoto N. 等人:“适应不同时间表的热量的大鼠的选定环境温度”Pflugers Archive。
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    0
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  • 通讯作者:
Shido, O., et al.: "Ambient temperatures preferred by humans acclimated to heat given at a fixed daily time"Physiol. Behav.. 72. 387-392 (2001)
Shido, O. 等人:“适应每天固定时间加热的人类首选的环境温度”Physiol。
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
Shido, O.: "Time Memory for heat exposure limited to a fixed daily time in heat-acclimated rats and humans"J. Therm. Biol.. (in press).
Shido, O.:“热适应大鼠和人类的热暴露时间记忆仅限于每日固定时间”J.
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Shido, O., et al.: "Exercise, Nutrition, and Environmental Stress"Cooper Publishing(in press).
Shido, O. 等人:“运动、营养和环境压力”Cooper Publishing(正在印刷中)。
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    0
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SHIDO Osamu其他文献

Long-Term Ultra-High Hydrostatic Pressurized Brown Rice Intake Prevents Bone Mineral Density Decline in Elderly Japanese Individuals
长期摄入超高静压糙米可防止日本老年人骨矿物质密度下降
  • DOI:
    10.3177/jnsv.65.s88
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    1.6
  • 作者:
    MATSUZAKI Kentaro;YANO Shozo;SUMIYOSHI Eri;SHIDO Osamu;KATSUBE Takuya;TABATA Mitsumasa;OKUDA Michiaki;SUGIMOTO Hachiro;YOSHINO Katsumi;HASHIMOTO Michio
  • 通讯作者:
    HASHIMOTO Michio

SHIDO Osamu的其他文献

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{{ truncateString('SHIDO Osamu', 18)}}的其他基金

Mechanism of heat acclimation-induced improvement of salivary secretion in rats
热驯化改善大鼠唾液分泌的机制
  • 批准号:
    23590278
  • 财政年份:
    2011
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of green odor on physiological responses to mental stress in humans
绿色气味对人类精神压力生理反应的影响
  • 批准号:
    20590231
  • 财政年份:
    2008
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of unknown cryogens existing in the blood of a hypothermic patient
低温患者血液中存在的未知冷冻剂的分析
  • 批准号:
    16390060
  • 财政年份:
    2004
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Identification of Novel Human Cryogen and the Mechanism of Hypothermia
新型人体冷冻剂的鉴定及低温机制
  • 批准号:
    14370023
  • 财政年份:
    2002
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Changes in thermoregulatory functions of humans after scclimation to heat given daily at a fixed time.
人类在适应每天固定时间的热量后体温调节功能的变化。
  • 批准号:
    08670077
  • 财政年份:
    1996
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
MODIFICATION OF NYCTHEMERAL VARIATIONS IN BODY CORE TEMPERATURE AFTER DAILY EXERCISE AT A FIXED TIME
每日固定时间锻炼后夜间身体核心温度变化的修正
  • 批准号:
    05670064
  • 财政年份:
    1993
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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将基因表达与冷驯化期间斑马鱼(Danio rerio)心脏功能增强的蛋白质调节联系起来
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离子动力ATP酶调节在果蝇冷驯化中的作用
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通过冷适应刺激人类非颤抖产热
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OEP16和OEP40在冷驯化中的作用(B05)
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冷驯化组织回路的分子生理学
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