Effects of physical training on insulin resistance

1)我们确定了96名日本年轻肥胖成年人这两个基因的序列。Cytb基因中标准氨基酸残基和替换氨基酸残基之间的理化差异显著小于ATP 6基因。因此，尽管Cytb基因具有很强的突变位点不对称性，但Cytb的氨基酸序列变异性比ATP 6小。2）在高果糖喂养的大鼠中研究了一氧化氮（NO）对胰岛素抵抗的影响。结论：NO可改善高果糖喂养诱导的胰岛素抵抗。3）研究了成熟和运动训练对大鼠骨骼肌胰岛素后受体信号转导组分基因表达和蛋白质含量的影响。运动训练可能影响IRS-1基因的转录调控和PI 3-kinase表达的转录后调控。

1) We determined the sequences of these two genes in 96 Japanese young obese adults. The physicochemical differences between the standard and the replaced amino acid residues were significantly smaller in the Cytb gene than in ATP6 one. Therefore amino acid sequences are less variable for Cytb than for ATP6 in spite of the strong mutational stand asymmetry for the Cytb gene.2) The effect of nitric oxide (NO) on insulin resistance was studied in high-fructose-fed rats. It could be concluded that NO can improve insulin resistance induced by high-fructose feeding.3) We examined the effects of maturation and exercise training on the gene expression and protein content of the components of post-insulin receptor signal transduction in rat skeletal muscle. Then exercise training may affect transcriptional regulation of the IRS-1 gene and posttranscriptional regulation of PI3-kinase expression.