Effects of physical training on insulin resistance

体能训练对胰岛素抵抗的影响

• 批准号: 11670066
• 负责人: SATO Yoshiharu
• 金额: $ 2.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670066/
• 关键词: Insulin resistance; Obesity; Mitochondrial DNA; Euglycemic clamp; autocrine; Physical training; GLUT-4; Insulin signal; 糖輸送能; 身体トレーニング; aging; 一酸化窒素(NO); アデノシン; 有酸素運動; レジスタンス運動; 糖尿病

1) We determined the sequences of these two genes in 96 Japanese young obese adults. The physicochemical differences between the standard and the replaced amino acid residues were significantly smaller in the Cytb gene than in ATP6 one. Therefore amino acid sequences are less variable for Cytb than for ATP6 in spite of the strong mutational stand asymmetry for the Cytb gene.2) The effect of nitric oxide (NO) on insulin resistance was studied in high-fructose-fed rats. It could be concluded that NO can improve insulin resistance induced by high-fructose feeding.3) We examined the effects of maturation and exercise training on the gene expression and protein content of the components of post-insulin receptor signal transduction in rat skeletal muscle. Then exercise training may affect transcriptional regulation of the IRS-1 gene and posttranscriptional regulation of PI3-kinase expression.

1)我们确定了96名日本年轻肥胖成年人这两个基因的序列。Cytb基因中标准氨基酸残基和替换氨基酸残基之间的理化差异显著小于ATP 6基因。因此，尽管Cytb基因具有很强的突变位点不对称性，但Cytb的氨基酸序列变异性比ATP 6小。2）在高果糖喂养的大鼠中研究了一氧化氮（NO）对胰岛素抵抗的影响。结论：NO可改善高果糖喂养诱导的胰岛素抵抗。3）研究了成熟和运动训练对大鼠骨骼肌胰岛素后受体信号转导组分基因表达和蛋白质含量的影响。运动训练可能影响IRS-1基因的转录调控和PI 3-kinase表达的转录后调控。

项目成果

Oshida et al: "Nitric oxide decreases insulin resistance induced by high-fructose feeding"Hormone and Metabolic Research. 32. 339-342 (2000)

Oshida 等人：“一氧化氮可降低高果糖喂养引起的胰岛素抵抗”激素和代谢研究。

T.Fushimi et al.: "Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats"J.Nutr. 131(7). 1973-1977 (2001)

T.Fushimi 等人：“醋酸喂养增强大鼠肝脏和骨骼肌中的糖原补充”J.Nutr。

M. Xu et al: "Mechanism of activation of branched- chain α-keto acid dehydrogenase complex by exercise"Biochemical and Biophysical Research Communications. 287. 752-756 (2001)

M. Xu 等人：“运动激活支链α-酮酸脱氢酶复合物的机制”生物化学和生物物理研究通讯287. 752-756 (2001)。

M.Nagasaki et al: "Exercise training prevents maturation-induced decreases m insulin receptor substrate-1 and phoshatidylinositol 3-kmase in rat skeletal muscle."Metabolism. 49(7). 1-7 (2000)

M.Nagasaki 等人：“运动训练可防止大鼠骨骼肌中胰岛素受体底物 1 和磷脂酰肌醇 3-km 酶成熟诱导的下降。”代谢。

Y.Yanagimoto et al: "Effects of walking on bone quality as determined by ultrasound in the elderly"Scand. J. Med. Sci. Sports. 10. 103-108 (2000)

Y.Yanagimoto 等人：“通过超声波确定老年人步行对骨质量的影响”扫描。