Intrafamilial transmission of Helicobacter pylori : Concordance of Helicobacter pylori infection on CagA among families.

这项研究调查了幽门螺杆菌（H.pylori）的传播是否发生在已婚夫妇之间，以及父母和子女之间是否存在与幽门螺杆菌传播相关的关系。设计-横断面研究在农村地区的居民中进行。我们通过血清学方法证实了hpylori的细胞毒素相关蛋白（CagA）和hpylori抗体。使用无条件逻辑回归模型对数据进行分析。参与者——研究对象是1910名年龄在22岁到79岁之间、居住在这个地区的志愿者。主要结果：已婚夫妇幽门螺杆菌血清阳性率有显著相关性（p<0.001），但在CagA阳性率方面无显著性差异（p=0.053）。母体与子代幽门螺杆菌血清阳性的比值比为8.08 (95% CI: 1.39 ~ 40.05)，父亲血清阳性子代幽门螺杆菌血清阳性子代的比值比为2.93 （95% CI: 0.25 ~ 33.85）。关于幽门螺杆菌血清阳性父母及其子女是否存在幽门螺杆菌的关系，13组中有11组（84.6%）对存在或不存在幽门螺杆菌的关系一致，而14组中有7组（50.0%）对父亲与子女的关系一致。结论：我们的研究结果表明，母亲对幽门螺杆菌传播的影响可能比父亲的影响更大

This study examines whether a transmission of Helicobacter pylori (H.pylori) occurs between married couples and also whether a correlation is found between a parent and an offspring that relates to the H.pylori transmission.Design-A cross sectional study was performed among residents living in a rural area. We serologically confirmed a cytotoxin-associated protein (CagA) of H.pylori using by a recombinant CagA in addition to antibodies to H.pylori. The data was analysed using unconditional logistic regression models.Participants-The study subjects were 1,910 volunteers between the ages of 22 and 79 years residing in this area.Main results-A significant association in married couples on H.pylori seropositivity was observed (p<0.001), but no significant difference was recognized between them with respect to the presence of CagA (p=0.053). Concerning the relationship between a parent and an offspring on H.pylori seropositivity, the odds ratio for seropositive offsprings in a seropositive mother group was 8.08 (95% CI : 1.39-40.05) and this value was 2.93 (95% CI : 0.25-33.85) for those in a seropositive father group. As to the association between H.pylori-seropositive parents and their H.pylori-seropositive offsprings on the presence of CagA, the relationship between a mother and her offspring, 11 groups (84.6%) of 13 groups were concordance about the existence or absence of CagA compared with 7 groups (50.0%) of 14 groups in the relationship between a father and his offspring.Conclusions-Our results suggest that maternal influence is likely to be more powerful than paternal influence on the transmission of H.pylori