Intrafamilial transmission of Helicobacter pylori : Concordance of Helicobacter pylori infection on CagA among families.

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This study examines whether a transmission of Helicobacter pylori (H.pylori) occurs between married couples and also whether a correlation is found between a parent and an offspring that relates to the H.pylori transmission.Design-A cross sectional study was performed among residents living in a rural area. We serologically confirmed a cytotoxin-associated protein (CagA) of H.pylori using by a recombinant CagA in addition to antibodies to H.pylori. The data was analysed using unconditional logistic regression models.Participants-The study subjects were 1,910 volunteers between the ages of 22 and 79 years residing in this area.Main results-A significant association in married couples on H.pylori seropositivity was observed (p<0.001), but no significant difference was recognized between them with respect to the presence of CagA (p=0.053). Concerning the relationship between a parent and an offspring on H.pylori seropositivity, the odds ratio for seropositive offsprings in a seropositive mother group was 8.08 (95% CI : 1.39-40.05) and this value was 2.93 (95% CI : 0.25-33.85) for those in a seropositive father group. As to the association between H.pylori-seropositive parents and their H.pylori-seropositive offsprings on the presence of CagA, the relationship between a mother and her offspring, 11 groups (84.6%) of 13 groups were concordance about the existence or absence of CagA compared with 7 groups (50.0%) of 14 groups in the relationship between a father and his offspring.Conclusions-Our results suggest that maternal influence is likely to be more powerful than paternal influence on the transmission of H.pylori