Intrafamilial transmission of Helicobacter pylori : Concordance of Helicobacter pylori infection on CagA among families.

幽门螺杆菌的家庭内传播：家庭间 CagA 幽门螺杆菌感染的一致性。

• 批准号: 11670356
• 负责人: UNE Hiroshi
• 金额: $ 1.98万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670356/
• 关键词: Helicobacter pylori; CagA; Transmission route; Intrafamilial transmission; Transmission between spouses; mother to child transmission; Father to child transmission

This study examines whether a transmission of Helicobacter pylori (H.pylori) occurs between married couples and also whether a correlation is found between a parent and an offspring that relates to the H.pylori transmission.Design-A cross sectional study was performed among residents living in a rural area. We serologically confirmed a cytotoxin-associated protein (CagA) of H.pylori using by a recombinant CagA in addition to antibodies to H.pylori. The data was analysed using unconditional logistic regression models.Participants-The study subjects were 1,910 volunteers between the ages of 22 and 79 years residing in this area.Main results-A significant association in married couples on H.pylori seropositivity was observed (p<0.001), but no significant difference was recognized between them with respect to the presence of CagA (p=0.053). Concerning the relationship between a parent and an offspring on H.pylori seropositivity, the odds ratio for seropositive offsprings in a seropositive mother group was 8.08 (95% CI : 1.39-40.05) and this value was 2.93 (95% CI : 0.25-33.85) for those in a seropositive father group. As to the association between H.pylori-seropositive parents and their H.pylori-seropositive offsprings on the presence of CagA, the relationship between a mother and her offspring, 11 groups (84.6%) of 13 groups were concordance about the existence or absence of CagA compared with 7 groups (50.0%) of 14 groups in the relationship between a father and his offspring.Conclusions-Our results suggest that maternal influence is likely to be more powerful than paternal influence on the transmission of H.pylori

这项研究调查了幽门螺杆菌（H.pylori）的传播是否发生在已婚夫妇之间，以及父母和子女之间是否存在与幽门螺杆菌传播相关的关系。设计-横断面研究在农村地区的居民中进行。我们通过血清学方法证实了hpylori的细胞毒素相关蛋白（CagA）和hpylori抗体。使用无条件逻辑回归模型对数据进行分析。参与者——研究对象是1910名年龄在22岁到79岁之间、居住在这个地区的志愿者。主要结果：已婚夫妇幽门螺杆菌血清阳性率有显著相关性（p<0.001），但在CagA阳性率方面无显著性差异（p=0.053）。母体与子代幽门螺杆菌血清阳性的比值比为8.08 (95% CI: 1.39 ~ 40.05)，父亲血清阳性子代幽门螺杆菌血清阳性子代的比值比为2.93 （95% CI: 0.25 ~ 33.85）。关于幽门螺杆菌血清阳性父母及其子女是否存在幽门螺杆菌的关系，13组中有11组（84.6%）对存在或不存在幽门螺杆菌的关系一致，而14组中有7组（50.0%）对父亲与子女的关系一致。结论：我们的研究结果表明，母亲对幽门螺杆菌传播的影响可能比父亲的影响更大

项目成果

Shibata K, Miyazaki M, Une H, et al.: "Green Tea Consumption and Chronic Atrophic Gastritis : A Cross-Sectional Study in a Green Tea Production Village"Journal of Epidemiology. 10(5). 310-316 (2000)

Shibata K、Miyazaki M、Une H 等人：“绿茶消费与慢性萎缩性胃炎：绿茶生产村的横断面研究”流行病学杂志。

Shibata K,Miyazaki M,Une H, et al: "Green Tea Consumption and Chronic Atrophic Gastritis : A Cross-Sectional Study in a Green Tea Production Village"Journal of Epidemiology. 10(5). 310-316 (2000)

Shibata K、Miyazaki M、Une H 等人：“绿茶消费与慢性萎缩性胃炎：绿茶生产村的横断面研究”流行病学杂志。