Epidemiological study on the relationship between ischemic heart disease and infection of Chlamydia pneumoniae.

缺血性心脏病与肺炎衣原体感染关系的流行病学研究。

• 批准号: 13670348
• 负责人: UNE Hiroshi
• 金额: $ 2.3万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670348/
• 关键词: Chlamydia pneumoniae; Ischemic heart disease; Risk factors; C.pneumoniae感染; C. pneumoniae感染; 患者対照研究

The purpose of this case-control study, carried out by examining for the presence of IgG and IgA antibodies, was to investigate the relationship between ischemic heart disease (IHD) and Chlamydia pneumoniae (C.pneumoniae) infection. Enrolled subjects were 625 cases. All cases were angiographically confirmed stenosis of coronary artery C.pneumoniae seropositivity was determined with an IgG-and an IgA-specific enzyme kit (Hitachikasei, Tokyo). The logistic regression model was applied to analyze a relationship between acute coronary syndromes (ACS) and controls in regard to C.pneumoniae seropositivity The data were analyzed with the Statistical Product and Service Solution (SPSS Inc, Chicago, IL). Probability values less than 0.05 were considered significant.Of 424 male patients, patients with stenosis of coronary arteries were 333. Non-stenosis cases with the result of within normal limit (WNL)' were 91cases. Controls without a history of IHD and with a resting ECG is normal were 47 cases. As regards IgG-seropositive rates of C.pneumoniae, 46.9% in a stenosis group, 51.9% in a WNL group and 57.4% in an ACS group. With respect to IgA-seropositive rates of C.pneumoniae, 62.5% in a stenosis group, 60.2% in a WNL group and 53.2% in an ACS group. No statistical significance was recognized on seropositivity of C.pneumoniae.'A relationship between ACS (31 cases) and C.pneumoniae infection was observed. All ACS were incidence cases. Controls (62 cases) were at random selected in outpatients. No statistical significance was -recognized on seropositivity of C.pneumoniae.

这项病例对照研究的目的是通过检查IgG和伊加抗体的存在来研究缺血性心脏病（IHD）与肺炎衣原体（C.pneumoniae）感染之间的关系。入组受试者为625例。所有病例均经血管造影证实冠状动脉狭窄。肺炎衣原体血清阳性用IgG和IgA特异性酶试剂盒（Hitachikasei，Tokyo）测定。应用逻辑回归模型分析急性冠状动脉综合征（ACS）和对照之间关于肺炎衣原体血清阳性的关系。使用统计产品和服务解决方案（SPSS Inc，芝加哥，IL）分析数据。424例男性患者中，333例冠状动脉狭窄。结果在正常范围（WNL）内的非狭窄病例为91例。对照组47例，无缺血性心脏病史，静息心电图正常。关于肺炎衣原体IgG血清阳性率，狭窄组为46.9%，WNL组为51.9%，ACS组为57.4%。肺炎衣原体IgA阳性率狭窄组为62.5%，WNL组为60.2%，ACS组为53.2%。肺炎衣原体血清阳性率无统计学意义。观察了ACS（31例）与肺炎衣原体感染的关系。ACS均为发病病例。对照组62例，随机选择门诊患者。肺炎衣原体血清阳性率无统计学意义。