An Epidemiological Study on Effects of Adiponectin and Leptin on Weight Gain

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This is a prospective study to clarify effects of adiponectin and leptin on weight gain. We classified into two groups with relatively high adiponectin level and relatively low adiponectin level, and two groups with relatively high leptin level and relatively low leptin level, and compared weight change in three years between the each two groups.The weights of the group with relatively high adiponectin level and that with relatively low adiponectin level increased +0.50kg and +0.29kg respectively. The difference between the two groups was not statistically significant. On the other hand, the weights of the group with relatively high leptin level and that with relatively low leptin level increased +0.16kg and +0.63kg respectively. The difference between the two groups was statistically significant.Our results suggest that leptin has suppressive effect on weight gain.