Evaluation of physical/chemical synergistic influence of the working environmental factor on hearing, and the application to the comfortable environment.

工作环境因素对听力的物理/化学协同影响评价及其在舒适环境中的应用。

• 批准号: 11670384
• 负责人: MIYASHITA Kazuhisa
• 金额: $ 2.43万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670384/
• 关键词: Hearing; Auditory Brainstem Response (ABR); Noise; Organic Solvents; Combined effect; Synergistic effect; 相乗影響

To clarify of evaluation of physical/chemical synergistic influence of the working environmental factor on hearing, and the application to the comfortable environment, animal experiments were carried out, and the male workers were examined.The subjects were male guinea pigs. Hearing threshold was measured by auditory brainstem response. The first experiment was only for methanol exposure, and methanol inhalation levels were 500 ppm, 900 ppm, 1500 ppm, 1900 ppm, 2400 ppm and 3000 ppm. The results of the first experiment demonstrated that methanol inhalation more than 1900ppm dose-dependently increased the hearing threshold. The second experiment was only for noise exposure, and noise exposure levels were 90, 100 and 105 dB SPL. The detection threshold in the 105 dB group was significantly increased. In the third experiment, guinea pigs were exposed to 1500 ppm or 1900 ppm methanol as sub-ototoxic concentration following 100 dB SPL white noise as sub-ototoxic level. In the combined group … More , the marked increase in the detection threshold was observed. The increase detection threshold was the greatest in the group of 1900 ppm methanol combined with noise.We measured hearing level and upper limit of hearing in 93 male workers occupationally exposed to organic solvents and noise. Environmental monitoring, biological monitoring and noise level measurement in workplaces were done. Most exposure level of organic solvents and/or noise were within the occupational exposure limits. The prevalence rate of upper limit of hearing below 75th percentile curve was higher in workers exposed to organic solvents and noise, and the upper limit of hearing was reduced in workers who were exposed for 5 years or more. This reduction was dose-dependent and was related to styrene concentrations in breathing-zone air and mandelic acid concentrations in urine. The results suggest that the probable synergistic effect of organic solvents and noise on hearing should be considered even when the exposures are within the occupational exposure limits. Less

为阐明作业环境因素对听力的物理/化学协同影响的评价及其在舒适环境中的应用，进行了动物实验，并对男性作业人员进行了检查，受试者为雄性豚鼠。用听性脑干反应测定听阈。第一个实验仅针对甲醇暴露，甲醇吸入水平为500 ppm、900 ppm、1500 ppm、1900 ppm、2400 ppm和3000 ppm。第一个实验的结果表明，甲醇吸入超过1900 ppm的剂量依赖性地增加听阈。第二个实验仅针对噪声暴露，噪声暴露水平分别为90、100和105 dB SPL。105 dB组的检测阈值显著增加。在第三个实验中，豚鼠暴露于1500 ppm或1900 ppm甲醇作为亚耳毒性浓度，随后暴露于100 dB SPL白色噪声作为亚耳毒性水平。联合组 ...更多信息 ，观察到检测阈值的显著增加。本文对93名接触有机溶剂和噪声的男工进行了听力水平和听力上限的测定。对作业场所进行了环境监测、生物监测和噪声测量。大部分有机溶剂和/或噪声的暴露水平在职业暴露限值范围内。接触有机溶剂和噪声的工人听力上限低于第75百分位数曲线的患病率较高，接触5年及以上的工人听力上限降低。这种减少是剂量依赖性的，并与呼吸区空气中的苯乙烯浓度和尿液中的扁桃酸浓度有关。结果提示，即使在职业接触限值范围内，有机溶剂和噪声对听力的影响可能存在协同效应。少

项目成果

Yoshihiro Minami et al: "Combined effects of noise and methanol on ABR (auditory brainstem response) in guinea pigs"Environmental Health and Preventive Medicine. 56(1). 258 (2001)

Yoshihiro Minami 等人：“噪音和甲醇对豚鼠 ABR（听觉脑干反应）的综合影响”环境健康与预防医学。

Hiroichi Yamamoto et al: "Combined effects of noise and methanol on ABR (auditory brainstem response) in guinea pigs (Part2)"Environmental Health and Preventive Medicine. 57(1). 343 (2002)

Hiroichi Yamamoto 等人：“噪音和甲醇对豚鼠 ABR（听觉脑干反应）的综合影响（第二部分）”环境健康与预防医学。

ゲオブンチュー・オラワン 他: "メタノール曝露のモルモットの聴覚に対する影響"産業衛生学雑誌. 第40巻. 399 (1998)

Geobunchu Olawan 等人：“甲醇暴露对豚鼠听力的影响”《工业卫生杂志》第 40 卷 399（1998 年）。

山本博一 他: "メタノールによる聴覚への影響に関する電気生理学的および組織学的検討"第27回有機溶剤中毒研究会. (1999)

Hirokazu Yamamoto 等人：“甲醇对听力影响的电生理学和组织学研究”第 27 届有机溶剂中毒研究组（1999 年）。

Kaewboonchoo Orawan et al.: "Effects of methanol inhalation on hearing threshold in guinea pigs"26^<th> International Congress on Occupational Health(ICOH2000). (2000)

Kaewboonchoo Orawan 等人：“吸入甲醇对豚鼠听力阈值的影响”第 26 届国际职业健康大会（ICOH2000）。