Analysis of association between anorexia nervosa and neuropeptide or amine receptor genes.

神经性厌食症患者存在内源性促肾上腺皮质激素释放因子（CRF）的高分泌，并可能与其发病机制有关。为了研究可能在神经性厌食症（AN）易感性中起重要作用的遗传因素，我们分析了15例有该疾病家族史的AN患者的CRF受体1型和2型基因。没有发现每个受体的多态性。对CRFR1和CRFR2外显子和边界区的PCR产物进行测序。但未发现碱基取代。

The hypersecretion of endogenous Corticotropin-releasing factor (CRF) is present in patients with anorexia nervosa and is supposed to be related to its pathogenesis.To examine genetic factors that may play a significant role in susceptibility to anorexia nervosa (AN), CRF receptor type 1 and type 2 genes were analyzed in 15 AN patients with a family history of this disease. Any polymorphism of each receptor was not found.PCR products of exons and boundary regions of CRFR1 as well as CRFR2 were sequenced. However, no base substitution was found.