Analysis of association between anorexia nervosa and neuropeptide or amine receptor genes.

神经性厌食症与神经肽或胺受体基因之间的关联分析。

• 批准号: 11671098
• 负责人: SUZUKI Mari
• 金额: $ 1.66万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671098/
• 关键词: Anorexia nervosa; Corticotropin-releasing factor receptor gene; RFLP; PCR; Corticotropin-releasing factor receptor

The hypersecretion of endogenous Corticotropin-releasing factor (CRF) is present in patients with anorexia nervosa and is supposed to be related to its pathogenesis.To examine genetic factors that may play a significant role in susceptibility to anorexia nervosa (AN), CRF receptor type 1 and type 2 genes were analyzed in 15 AN patients with a family history of this disease. Any polymorphism of each receptor was not found.PCR products of exons and boundary regions of CRFR1 as well as CRFR2 were sequenced. However, no base substitution was found.

为探讨神经性厌食症（anorexia nervosa，AN）易感性的遗传因素，对15例有AN家族史的AN患者进行了CRF受体1型和2型基因检测。对CRFR1和CRFR2的外显子和边界区PCR产物进行测序。然而，没有发现碱基替换。

项目成果

Mari Hotta et al.: "The relationship between bone turnover and body weight, Serum IGF-1 and serum IGF binding protein levels in patients with anorexia nervosa."J Clin Endocrinol Metab. 85(1). 200-206 (2000)

Mari Hotta 等人：“神经性厌食症患者骨转换与体重、血清 IGF-1 和血清 IGF 结合蛋白水平之间的关系。”J Clin Endocrinol Metab。

Mari Hotta et al.: "Fibroblast growth factor inhibits locomotor activity as well as feeding behavior of rats."Eur J Pham. (in press). (2001)

Mari Hotta 等人：“成纤维细胞生长因子抑制大鼠的运动活动和进食行为。”Eur J Pham。

堀田眞理 他: "内分泌疾患総合医療センター内科における神経性食欲不振症患者の実態-1999年1年間の初診患者の検討-"東京女子医科大学雑誌. 71. 147-154 (2001)

Mari Hotta等：“内分泌疾病综合医疗中心内科神经性厌食症患者的实际情况-1999年首次患者的检查”东京女子医科大学杂志71. 147-154（2001年）。 ）

Izumi Fukuda, Mari Hotta et al.: "Decreased serum levels of acid-labile subunit in patients with anorexia nervosa."J Clin Endocrinol Metab. 84(6). 2034-2036 (1999)

Izumi Fukuda、Mari Hotta 等人：“神经性厌食症患者酸不稳定亚基的血清水平降低。”J Clin Endocrinol Metab。

鈴木真理: "乙女心と拒食症"インターメディカル出版. 173 (1999)

铃木麻里：《少女心与厌食症》医学出版173（1999）。