The effects of ghrelin on electrogastrography in anorexia nervosa

为了开发一种新的治疗神经性厌食症的药物，我们旨在利用胃电图（EGG）作为一种无创技术来研究胃饥饿素对胃功能的影响。由于日本传统药物利空之藤（TJ-43）刺激胃饥饿素分泌，我们研究了TJ-43对神经性厌食症患者胃电活动的影响。神经性厌食症患者卵细胞正常功率%和心律失常%分别显著低于和高于健康对照组。与50ml水负荷相比，口服50ml TJ-43可显著降低神经性厌食症患者egr %心律失常。TJ-43可能改善神经性厌食症患者的胃肌电节律，提示胃饥饿素对食欲的影响可能与改善胃肌电活动有关。

To develop a possibly new medical treatment for anorexia nervosa, we aimed to investigate the effects of ghrelin on gastric function by using electrogastrography (EGG) as a non-invasive technique. Because Rikkunshito (TJ-43), a traditional Japanese medicine, stimulates ghrelin secretion, we studied the effects of TJ-43 on the gastric electrical activity of patients with anorexia nervosa. The % normal power and % arrhythmia of EGG in patients with anorexia nervosa were significantly lower and higher than those of healthy controls, respectively. Oral administration with 5g TJ-43 resolved in 50ml water significantly decreased % arrhythmia of EGG in patients with anorexia nervosa compared to the 50ml water load. TJ-43 may improve gastric myoelectrical rhythms in patients with anorexia nervosa, suggesting that the effect of ghrelin on appetite would be related to amelioration of gastric myoelectric activity.