Regulation of smooth muscle contraction for the dynamic obstruction of benign prostatic hyperplasia

豚鼠输精管平滑肌收缩是由交感神经递质去甲肾上腺素和ATP的释放介导的。本研究旨在探讨电刺激诱发猪输精管河豚毒素敏感收缩的机制。10或50次5或40 Hz脉冲ES引起的等长收缩由α，（肾上腺素能）包括α1早和α1晚，N-ATP（神经ATP）和α1-ATP（α1依赖的非神经ATP）三种成分组成，分别由1 μ m吡唑嗪或300 μ m苏拉明分离。两个硝苯地平敏感和一个尼卡地平敏感的Ca2+通道参与

Smooth muscle contractions of the guinea-pig vas deferens are mediated by the release of the sympathetic contransmitters noradrenaline and ATP. The present study was carried out to investigate the mechanism by which electrical stimulation (ES) evoked the tetrodotoxin-sensitive contractions in the fuimea-pig vas deferens. The isometric contractions evoked by ES with 10 or 50 pulses delivered at 5 or 40 Hz consisted of three components, α, (adrenergic) including α1early and α1-late, N-ATP(neural ATP) and α1-ATP(α1-dependent non-neural ATP), which were isolated by 1 uM prazosin or 300 uM suramin. Two nifedipine-sensitive and one nicardipine-senstive Ca2+ channels participated