MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE

设计替代框架和触发机制是一个有趣的挑战，其目标是产生一种在受控条件下可以被激活的稳定的烯二酶，特别是在将细胞毒性导向特定病原体或组织的方法中。在烯二炔体系中发现了简单的环芳构化触发器。这种烯二因化合物被脱保护激活来切割DNA。

It is an interesting challenge to design alternate frameworks and triggering mechanisms, with the goal of producing a stable enediyne which can be activated under controlled conditions, especially in away which directs the cytotoxicity toward a specific pathogen or tissue.I found simple trigger of cycloaromatization in enediyne system. This enediyne compound were activated by deprotection to cleave DNA.