MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE

设计替代框架和触发机制是一个有趣的挑战，目标是产生稳定的、可以在受控条件下激活的烯二炔，特别是在将细胞毒性定向到特定病原体或组织的情况下。我在烯二炔体系中发现了简单的环芳构化触发机制。这种烯二炔化合物被去保护激活以裂解DNA。

It is an interesting challenge to design alternate frameworks and triggering mechanisms, with the goal of producing a stable enediyne which can be activated under controlled conditions, especially in away which directs the cytotoxicity toward a specific pathogen or tissue.I found simple trigger of cycloaromatization in enediyne system. This enediyne compound were activated by deprotection to cleave DNA.