A health program to prevent a patient who received a gastrectomy from bone metabolism disorder

一项预防接受胃切除术的患者出现骨代谢紊乱的健康计划

• 批准号: 11672379
• 负责人: KAWAMOTO Rieko
• 金额: $ 2.11万
• 依托单位: University of Occupational and Environmental Health (2001-2002)佐賀医科大学 (1999-2000)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11672379/
• 关键词: gastrectomy; bone metabolism; bone cell density; physical activity; dietary life; ultrasound densitometer; 骨密度測定; 骨量測定

The aim of this study is to examine effects of bone metabolism impairment after a gastrectomy, and the effects of dietary life and physical activity on bone density, in order to obtain basic information for education regarding lifestyle which prevent osteoporosis.The study subjects were 39 male patients aged 80 years old or less who had been diagnosed as having gastric cancer in A and B medical colleges and had received a gastrectomy. All subjects gave their informed consent. The level of the bone metabolism impairment was examined by bone cell density measurement, by ultrasound densitometer and measurement of bone metabolism parameters, i.e. ALP_3, BAP, DPD, NTx, compensation Ca. Physical activity was measured by the number of steps, and dietary life was investigated using a questionnaire.In both medical colleges, the SOS value, which is an index to the bone metabolism impairment, decreased three weeks after the gastrectomy. Although the SOS value recovered once, it appears to decreas … More e after sixth months again. Afterwards, it recovered to the preoperative level. In A medical college, the levels of ALP_3 and BAP, which are the osteogenesis markers, significantly decreased 3 weeks after gastrectomy and increased three months later. DPD level, which is a bone resorption marker, increased significantly. In B medical college, the levels of ALP_3 and BAP significantly decreased three weeks after gastrectomy, and increased three months later. However, DPD level significantly increased three weeks after gastrectomy, and significantly decreased after three months. NTx levels showed a tendency to increase at anytime after gastrectomy and significantly increased one year later compared with preoperative level. In both universities, the effect of physical activity and dietary life on the bone density was not recognized. Though the bone metabolism impairment appeared 3 weeks after the gastrectomy, the bone formation process after bone resorption was affected by individual differences. Less

本研究以A、B医学院校确诊胃癌的80岁以下男性患者39例为研究对象，探讨胃切除术后骨代谢障碍的影响，以及饮食生活和体力活动对骨密度的影响，为预防骨质疏松症的生活方式教育提供基本信息。所有受试者均签署了知情同意书。通过骨细胞密度测定、超声骨密度仪及骨代谢指标ALP_3、BAP、DPD、NTx、代偿钙（Ca）的测定，评价骨代谢受损程度。在两所医学院，SOS值，这是一个指标，骨代谢障碍，胃切除术后三周下降。虽然SOS值恢复了一次，但似乎在下降， ...更多信息 六个月后，再次。之后，它恢复到术前水平。在A医学院，成骨标志物ALP_3和BAP在胃切除术后3周显著降低，3个月后升高。骨吸收标志物DPD水平显著升高。在B医学院，胃切除术后3周ALP_3和BAP水平显著降低，3个月后升高。而DPD水平在胃切除术后3周显著升高，3个月后显著降低。NTx水平在胃切除术后的任何时候都有升高的趋势，1年后与术前水平相比显著升高。在这两所大学中，体力活动和饮食生活对骨密度的影响没有得到承认。虽然胃切除术后3周出现骨代谢障碍，但骨吸收后的骨形成过程受个体差异的影响。少