NanoMslide: plasmon-enhanced ptychographic phase microscopy

NanoMslide：等离子体增强叠层相位显微镜

• 批准号: DP220103679
• 负责人: Prof Brian Abbey
• 金额: $ 19.46万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-26 至 2025-07-25
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103679
• 关键词: NanoMslide; plasmon; enhanced; ptychographic; phase

This proposal aims to combine recent advances in metamaterials and quantitative phase imaging to probe the near-surface refractive index properties of cells and tissues. The proposed technique delivers orders of magnitude improvement in terms of sensitivity over conventional phase contrast microscopy and will be used to provide new insights into the molecular basis for disease. This project will result in a new approach to stain-free, label free, tissue characterisation that will benefit a diverse range of applications in biological imaging and aid in the development of this nanotechnology platform into a long-term, sustainable business for Australia.

这一提议旨在将超材料和定量相位成像的最新进展结合起来，以探索细胞和组织的近表面折射率特性。这项拟议的技术在灵敏度方面比传统的相差显微镜提高了几个数量级，并将用于为疾病的分子基础提供新的见解。该项目将产生一种无污染、无标签的组织表征的新方法，这将使生物成像中的各种应用受益，并有助于将这一纳米技术平台发展成为澳大利亚的长期、可持续的业务。