Development of the artificial organs from human stem cells.
利用人类干细胞开发人造器官。
基本信息
- 批准号:11794032
- 负责人:
- 金额:$ 9.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for University and Society Collaboration
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
On this research, we tried to develop new technologies to regenerate the liver, skin-hair, and cartilagebone from the adult tissue stem cells.1. Liver. We established several cell clones from the liver epithelium and succeeded to induce the differentiation of them to the hepatocytes in vitro. We also tried and partially succeeded to recover the liver function on the experimental animals by using these cells.2. Skin-Hair. We developed a new-technology to accelerate the formation of the cultured epithelium by using Sonic hedgehog expressing feeder cells. This result indicates that the application of the knowledge from the molecular biology is useful to develop the tissue engineering.3. Mesenchyme. We obtained mesenchymal stem cells from the human bone marrow and succeeded to differentiate them to the osteoblast, chondrocytes, and adipocytes. We are trying to apply these cells to the plastic surgery.The connective research among regions was very powerful and useful for the combined and prompt research.
在这项研究中,我们试图开发新的技术,从成体组织干细胞再生肝脏,皮肤毛发和软骨骨。肝脏我们从肝上皮细胞中建立了几个细胞克隆,并成功地在体外诱导它们向肝细胞分化。我们还尝试并部分成功地利用这些细胞恢复了实验动物的肝功能.光头仔我们开发了一种新的技术,通过使用Sonic hedgehog表达饲养细胞来加速培养上皮的形成。这一结果表明,分子生物学知识的应用对组织工程的发展是有益的.间质我们从人骨髓中获得间充质干细胞,并成功地将其分化为成骨细胞、软骨细胞和脂肪细胞。我们正试图将这些细胞应用于整形外科,区域间的联系研究是非常有力的,有利于联合和快速的研究。
项目成果
期刊论文数量(68)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
寺田邦彦: "肝幹細胞を利用した肝組織の再構成"医学のあゆみ. 196. 383-386 (2001)
Kunihiko Terada:“利用肝干细胞重建肝组织”医学史 196. 383-386 (2001)。
- DOI:
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- 影响因子:0
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- 通讯作者:
Harada M, et al.: "A Mutation of Wilson's Disease Protein, ATP7B, Is Degraded in the Proteasomes and Forms Protein Aggregates"Gastroenterology. 120・4. 967-974 (2001)
Harada M 等人:“威尔逊氏病蛋白 ATP7B 的突变在蛋白酶体中被降解并形成蛋白聚集体”胃肠病学 120・4(2001)。
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- 影响因子:0
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寺田邦彦、他: "幹細胞を用いたミニ肝臓の形成"Molecular Medicine. 38. 16-22 (2001)
Kunihiko Terada 等人:“利用干细胞形成微型肝脏”《分子医学》38. 16-22 (2001)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Sugiyama T, et al.: "Reconstituteion of hepatic tissue using liver stem cells. In Growth , Proliferation, and Apoptosis in Hepatocytes (Okita K., ed.)"Springer-Verlag, Tokyo. 100 (2002)
Sugiyama T等人:“使用肝干细胞重建肝组织。肝细胞的生长、增殖和凋亡(Okita K.编辑)”Springer-Verlag,东京。
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- 影响因子:0
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寺田邦彦、他: "肝幹細胞と毛幹細胞"化学フロンティア(3)再生医工学(筏義人、編).化学同人.京都. 254 (2001)
Kunihiko Terada等人:“肝脏干细胞和毛发干细胞”化学前沿(3)再生医学工程(加藤义人编辑)京都254(2001)。
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SUGIYAMA Toshihiro其他文献
SUGIYAMA Toshihiro的其他文献
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{{ truncateString('SUGIYAMA Toshihiro', 18)}}的其他基金
Development of the cell transplantation therapy for the tooth regeneration using the committed progenitor cell of the tooth established from the tooth germ
利用从牙胚建立的牙齿定向祖细胞开发用于牙齿再生的细胞移植疗法
- 批准号:
18300159 - 财政年份:2006
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Search for facto s that induce transdifferentiation from liver stem cell to epitheial cells of digestive gland and development with tissue engineering
利用组织工程寻找诱导肝干细胞向消化腺上皮细胞转分化及发育的因子
- 批准号:
15300154 - 财政年份:2003
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Establishment of isolation procedure of human hepatic stem cell and tissue engineering technique to reconstitute hepatic tissue using the stem cell.
人肝干细胞分离方法的建立及利用干细胞重建肝组织的组织工程技术。
- 批准号:
11558101 - 财政年份:1999
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The expression and regulation of the liver enriched transcription factors involving in liver differentiation
肝脏富集转录因子参与肝脏分化的表达及调控
- 批准号:
09670120 - 财政年份:1997
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An antibody against single-stranded DNA useful for detecting apoptotic cells : production and applications for development, differentiation and carcinogenesis
用于检测凋亡细胞的单链 DNA 抗体:生产及其在发育、分化和癌变中的应用
- 批准号:
08557013 - 财政年份:1996
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Correlation between the spontaneous hepatitis and hepatoma and the disorder of methyl group metabolism in LEC rats
LEC大鼠自发性肝炎、肝癌与甲基代谢紊乱的相关性
- 批准号:
03670140 - 财政年份:1991
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Abnormal Expression of Cytochrome P-450 in LEC Rats with Metabolic Predisposition to Spontaneous Hepatitis
具有自发性肝炎代谢倾向的 LEC 大鼠细胞色素 P-450 的异常表达
- 批准号:
01570157 - 财政年份:1989
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Relationship between debromination reaction of halogen compounds and organ toxicity
卤素化合物的脱溴反应与器官毒性的关系
- 批准号:
60570131 - 财政年份:1985
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
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复兴干细胞有助于肝脏再生吗?
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- 批准号:
DGECR-2020-00053 - 财政年份:2020
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Development of a low-invasive, high-efficient liver regeneration therapy by infusion of cultured bone marrow mesenchymal stem cells combined with interventional radiology
培养骨髓间充质干细胞输注结合介入放射学开发低创高效肝再生疗法
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17K10441 - 财政年份:2017
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Gene transfer programming of mesenchymal stem cells for repairing and regeneration of the liver, and its application for liver regeneration therapy
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23590968 - 财政年份:2011
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