Development of the cell transplantation therapy for the tooth regeneration using the committed progenitor cell of the tooth established from the tooth germ

利用从牙胚建立的牙齿定向祖细胞开发用于牙齿再生的细胞移植疗法

• 批准号: 18300159
• 负责人: SUGIYAMA Toshihiro
• 金额: $ 11.4万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18300159/
• 关键词: 細胞工学; 歯胚; エナメル芽細胞; 象牙芽細胞; 歯再生

マウス胎児の歯牙から象牙芽前駆細胞(odontoblast-lineage cell (OLC))を樹立した。そこで、ヌードマウスの皮膚にPura Matrixに播種したOLCを移植したところ、8週間後に移植したOLCの約25%に有意な石灰化したコラーゲン塊が出現した。次に、歯胚上皮組織とOLCの三次元培養系、及びin vivo三次元再構成体の腎移植系において歯冠の形成を観察できた。

Odontoblast-lineage cells (OLC) are established in the fetal teeth. About 25% of the OLC transplanted after 8 weeks was intentionally calcified. The formation of dental crowns in vitro and in vivo three-dimensional culture systems for dental epithelial tissue and OLC was observed.

项目成果

Expression and localization of Regenerating gene I in a rat liver regeneration model.

再生基因 I 在大鼠肝再生模型中的表达和定位。

• 发表时间: 2009
• 期刊: Biochemical and Biophysical Research Communications 380(3)
• 作者: Ueno;Yasuharu
• 通讯作者: Yasuharu

Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver

• DOI: 10.2220/biomedres.28.323
• 发表时间: 2007-12-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Hirasawa, Fujiko;Kawagoe, Masami;Sugiyama, Toshihiro
• 通讯作者: Sugiyama, Toshihiro

REG I expression predicts long-term survival among locally advanced thoracic suamous cell eophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy

REG I表达预测接受新辅助放化疗和食管切除术治疗的局部晚期胸鳞状细胞食管癌患者的长期生存

• 发表时间: 2006
• 期刊: Ann. Surg. Oncol 13
• 作者: Motoyama S;Sugiyama T;Ueno Y;Okamoto H;Takasawa S;Nanjo H;Watanabe H;Maruyama K;Okuyama M;Ogawa J.
• 通讯作者: Ogawa J.

REG I expression predicts long-term survival among locally abvanced thoracic suamous cell eophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy.

REG I 表达可预测接受新辅助放化疗和食管切除术治疗的局部晚期胸鳞状细胞食管癌患者的长期生存。

• 发表时间: 2006
• 期刊: Ann. Surg. Oncol., 13
• 作者: Yamaoka Y;Fujiwara K;Takamatsu T;Motoyama S. et al.
• 通讯作者: Motoyama S. et al.

SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines

• DOI: 10.1038/sj.onc.1209068
• 发表时间: 2006-01-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Watanabe, H;Mizutani, T;Iba, H
• 通讯作者: Iba, H