Liver regeneration using stem cells from hteeth (SHED) for congenital metabol

使用来自牙齿的干细胞（SHED）进行先天性代谢的肝脏再生

• 批准号: 23659618
• 负责人: TAGUCHI Tomoaki
• 金额: $ 2.25万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659618/
• 关键词: 移植外科学; 肝細胞移植; 乳歯幹細胞; 立体物; 免疫寛容; 先天性代謝異常症; 先天性凝固異常症; 肝移植; 再生医療

SHED was shown to have the character of MSC as well as HSC. SHED low expression of HLA. SHED was successfully induced to the hepatocyte-like cell in medium. These hepatocyte-like cells were settled to the damaged liver tissue in CCl4 induced liver chirrhosis as well as Wilson disease. These cells could compose the sphere structure. On the other hand, 3D liver structure was built using 3D bioprinter.

SHED具有MSC和HSC的特性。SHED低表达HLA。在培养基中成功诱导SHED为肝细胞样细胞。这些肝细胞样细胞在CCl_4诱导的肝硬化和Wilson病的损伤肝组织中定居。这些细胞可以组成球状结构。另一方面，使用3D生物打印机构建3D肝脏结构。

项目成果

Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single-strand RNA.

通过单链 RNA 刺激，有效诱导脐带血 NK 细胞产生 IFN-γ。

• 发表时间: 2011
• 期刊: J Clin Immunol
• 影响因子: 9.1
• 作者: Eljaafari FM;Takada H;Tanaka T;Doi T;Ohga S;Hara T
• 通讯作者: Hara T

The Outcome of Biliary Atresia in Transplantation Era：A Single-Center Experience

移植时代胆道闭锁的结局：单中心经验

• 发表时间: 2012
• 作者: Alatas FS;Yamaza T;Yamaza H;Hayashida M;Yanagi Y;KukitaT;Nonaka K;Ohga S;Taguchi T;Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T
• 通讯作者: Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T

Sessile Serrated Adenoma With Early Neoplastic Progression: A Clinicopathologic and Molecular Study

• DOI: 10.1097/pas.0b013e318205df36
• 发表时间: 2011-02-01
• 期刊: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
• 影响因子: 5.6
• 作者: Fujita, Kohei;Yamamoto, Hidetaka;Oda, Yoshinao
• 通讯作者: Oda, Yoshinao

Correlation between the Number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification.

无 MYCN 扩增的二倍体神经母细胞瘤节段染色体畸变数量与诊断年龄之间的相关性。

• 发表时间: 2011
• 期刊: Journal of Pediatric Surgery
• 影响因子: 2.4
• 作者: Sozaki R;Tajiri T;Teshiba R;Kinoshita Y;Yosue R;Kohashi K;Oda Y;Taguchi T
• 通讯作者: Taguchi T

Trans-differentiation and spheroid formation of hepatocyte-like cells of stem cells from human exfoliated deciduous teeth ～ A New treatment tool for coagulopathy and metabolic disease ～

人脱落乳牙干细胞肝细胞样细胞的转分化和球状形成～凝血病和代谢性疾病的新治疗工具～

• 作者: Alatas FS;Yamaza T;Yamaza H;Hayashida M;Yanagi Y;Kukita T;Nonaka K;Ohga S;Taguchi T
• 通讯作者: Taguchi T