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Molecular basis of circadian rhythms : function of clock genes

昼夜节律的分子基础：时钟基因的功能

基本信息

批准号：
11694199
负责人：
KONDO Takao
金额：
$ 6.66万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11694199/
关键词：
cyanobacteria mouse circadian clock clock genes Drosophila protein interaction suprachiasmatic nuclei phosphorylation

项目摘要

Circadian clock functions in almost all organisms and function to adapt the life to daily alternating environment. Molecular mechanism of the circadian clock is one of the most interesting subject of basic biology nowadays. Recent advances in molecular genetic approaches to the clock genes identified several clock genes in model organisms. Recently, clock genes of cyanobacteria and mammals was cloned by Japanese scientists and US-Japan collaboration become more important for advance in this field. The project had been applied as International research grants and accepted as basic research grants for 1999-2000. The Center of the biological timing (NSF) is the partner group of US scientists. To promote collaboration and individual research projects of the project members, the first symposium had been held at Hawaii, in 1999 and the second at Kyoto in 2000. In both symposiums, many non-member scientists were also invited and there were very active presentation and discussion, which then trigger collaboration and simulate research of project members. In addition to two symposiums, domestic workshop was held at Inuyama, Aichi, in late 1999 to promote and activate young Japanese scientist who, otherwise, would not have a chance to discuss because many of them belong to different communities.With these activities, new collaboration between Japan and US was started and some collaborations which already started were promoted. Also, the information of the symposium were very stimulus for each project members. After all, with this project, understanding for molecular basis of the circadian clock has been greatly advanced and we recognized that simple negative feedback dogma is insufficient to explain circadian characteristics that features the circadian oscillate to be adaptive. To obtain full understanding the clock at molecular level, many unknown processes and whole cellular metabolism should be included in the circadian system.

生物钟在几乎所有生物体中都起作用，使生命适应每天交替的环境。昼夜节律钟的分子机制是当今基础生物学中最有趣的课题之一。时钟基因的分子遗传学方法的最新进展确定了模式生物中的几个时钟基因。最近，日本科学家克隆了蓝藻和哺乳动物的时钟基因，美日合作对这一领域的进展变得更加重要。该项目已申请成为1999-2000年度的国际研究补助金，并被接受为基本研究补助金。生物计时中心（NSF）是美国科学家的合作伙伴组织。为促进合作和促进项目成员的个别研究项目，1999年在夏威夷举行了第一次专题讨论会，2000年在京都举行了第二次专题讨论会。在这两次研讨会上，也邀请了许多非成员科学家，并进行了非常活跃的演讲和讨论，从而引发了项目成员的合作和模拟研究。除了两次研讨会之外，1999年底在爱知县的Inuyama举行了国内研讨会，以促进和激励年轻的日本科学家，否则他们中的许多人属于不同的社区，因此没有机会进行讨论。通过这些活动，日美之间开始了新的合作，并促进了一些已经开始的合作。此外，研讨会的信息对每个项目成员都很有激励作用。毕竟，通过这个项目，对生物钟分子基础的理解已经大大提高，我们认识到简单的负反馈教条不足以解释昼夜节律振荡具有适应性的昼夜节律特征。为了在分子水平上充分了解生物钟，许多未知的过程和整个细胞代谢应该包括在昼夜节律系统中。