Engineering T cells to promote peripheral immunity

改造 T 细胞以促进外周免疫

• 批准号: DE220100165
• 负责人: Dr Raissa Fonseca
• 金额: $ 32.52万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-11-14
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100165
• 关键词: Engineering; cells; promote; peripheral; immunity

Tissue-resident memory T cells (TRM) are key for immune protection against infections and cancer. This has led to much interest in understanding how these immune cells develop, although elucidation of molecules that regulate TRM are still scarce. This project aims to (i) identify genetic drivers of TRM in peripheral organs and (ii) modulate TRM generation utilising state-of-the-art genetic engineering techniques. Expected outcomes include generating new knowledge that will contribute to the development of novel therapeutics against infectious disease and cancer, together with the benefit of promoting national and international collaboration with the ultimate goal of improving health.

组织驻留记忆T细胞（TRM）是免疫保护对抗感染和癌症的关键。这引起了人们对了解这些免疫细胞如何发育的兴趣，尽管对调节TRM的分子的阐明仍然很少。该项目旨在（i）识别外周器官中TRM的遗传驱动因素，以及（ii）利用最先进的基因工程技术调节TRM的产生。预期成果包括产生新的知识，这将有助于开发新的治疗传染病和癌症的方法，以及促进国家和国际合作的好处，最终目标是改善健康。