Mucin phenotype and molecular genetic analysis of gastric cancer
胃癌粘蛋白表型及分子遗传学分析
基本信息
- 批准号:12670178
- 负责人:
- 金额:$ 1.98万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Genetic analysis of gastric cancer is summarized in two parts. I. Mucin phenotype and genetic analysis of well differentiated early gastric adenocarcinoma : Well differentiated early gastric adenocarcinoma cases were classified into gastric, intestinal, and mixed gastric/intestinal phenotype, and were subjected to genetic analysis. 1) Well differentiated mucosal tumor with cytoplasmic mucin may become less differentiated and may loose mucin by genetic progression. 2) There are monoclonal tumor cells possessing biphasic phenotype, 3) Some cases show carcinoma foci with gastric and intestinal phenotype side by side. This is caused by subclonal emergence through genetic progression and/or genetic divergence. 4) Methylation of hMLHl was detected in intestinal metaplasia and even normal appearing mucosa as well as carcinoma portions. Altogether, there are many well differentiated adenocarcinoma cases showing gastric and mixed phenotype. These phenotypic diversity is conferred by bidirection … More al phenotypic ability of the tumor clones as well as genetic progression and/or genetic divergence. Adenocarcinoma cells with mixed phenotype may emerge from damaged mucosa with incomplete metaplasia or mucosal cells with mixed phenotypic ability. Furthermore, we identified genetic pathways from mucosal well differentiated carcinoma progressing to less differentiated forms. II. Genetic analysis of Alpha fetoprotein producing gastric cancer (AFP-GC) : AFP-GC is an unusual form of aggressive adenocarcinoma showing complex histological pictures including medullary pattern, enteroblastic, and hepatoid differentiation. In the present study, multiple foci from 20 cases of AFP-GC were microdissected and LOH analysis was performed. Most tumors were single clonal with extensive LOH (an average fractional allelic loss of0.79). Presence of heterogeneous patterns of LOH suggested that the AFP producing medullary, enteroblastic and hepatoid carcinoma foci may evolve through genetic progression and/or genetic divergence. Less
对胃癌的基因分析分为两部分进行综述。一、高分化早期胃腺癌粘蛋白表型及基因分析:将高分化早期胃腺癌分为胃型、肠型和胃肠混合型,并进行遗传分析。1)分化较好的粘液性肿瘤与细胞质粘蛋白的分化程度较低,并可能通过遗传进展使粘蛋白松散。2)单克隆性肿瘤细胞具有双相表型;3)部分病例癌灶与胃、肠表型并存。这是由于通过遗传进程和/或遗传分化而出现的亚克隆。4)肠上皮化生、正常粘膜及癌组织中均有hMLH1基因甲基化。总体而言,有许多高分化腺癌病例表现为胃型和混合型。这些表型多样性是由双向…赋予的肿瘤克隆的更多表型能力以及遗传进展和/或遗传分化。混合表型的腺癌细胞可能来自不完全化生的受损粘膜,也可能是具有混合表型能力的粘膜细胞。此外,我们还发现了从粘膜高分化癌发展到低分化癌的遗传途径。AFP-GC是一种罕见的侵袭性腺癌,具有复杂的组织学特征,包括髓样分化、肠母细胞分化和肝样分化。本研究对20例AFP-GC的多个病灶进行了显微解剖和杂合性丢失分析。大多数肿瘤是单克隆性的,有广泛的杂合性缺失(平均部分等位基因丢失0.79)。异质性LOH的存在提示AFP产生髓样癌、肠母细胞癌和肝细胞癌病灶可能是通过遗传进展和/或遗传分化来进化的。较少
项目成果
期刊论文数量(25)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yamano, M., Fujii, H., et al.: "Genetic progression and divergence in pancreatic carcinoma"American Journal of Pathology. 156. 2123-2133 (2000)
Yamano, M., Fujii, H., et al.:“胰腺癌的遗传进展和分化”美国病理学杂志。
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- 影响因子:0
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Jiang WW, Fujii H, et al.: "Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity"Cancer. 92. 2356-2349 (2001)
Jiang WW,Fujii H,等:“从白斑到口腔白斑早期癌化病灶杂合性丢失的累积增加”癌症。
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- 影响因子:0
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Kushima, M., Fujii, H., et al.: "Simultaneous squamous cell carcinomas of the uterine cervix and upper genital tract : loss of heterozygosity analysis demonstrates clonal neoplasms of cervical origin"International Journal of Gynecololgical Patholology. 20
Kushima, M., Fujii, H., et al.:“子宫颈和上生殖道同时发生的鳞状细胞癌:杂合性丢失分析表明宫颈起源的克隆性肿瘤”国际妇科病理学杂志。
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- 影响因子:0
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Jiang, W.W., Fujii, H., et al: "Acumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity."Cancer. 92(9). 2349-2356 (2001)
Jiang,W.W.,Fujii,H.,等人:“从白斑到口腔白斑早期癌化病灶的杂合性损失累积增加。”癌症。
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- 影响因子:0
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Fujii, H., et al.: "Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity,"Cancer Research,. 60(1). 114-120 (2000)
Fujii, H., et al.:“妇科癌肉瘤克隆进化中常见的遗传异质性及其对表型多样性的影响”,癌症研究,。
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FUJII Hiroaki其他文献
Jump ability in relation to ball speed during windmill pitching by female softball pitchers:
女垒球投手风车投球时的跳跃能力与球速的关系:
- DOI:
10.5432/jjpehss.21056 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
KARIYAMA Yasushi;TOYODA Ayano;FUJII Hiroaki - 通讯作者:
FUJII Hiroaki
FUJII Hiroaki的其他文献
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{{ truncateString('FUJII Hiroaki', 18)}}的其他基金
Research on the training method of the throwing event which paid its attention to individual physical strength and technical characteristics
注重个人体力和技术特点的投掷项目训练方法研究
- 批准号:
24700681 - 财政年份:2012
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Molecular pathologic analysis of Niban gene expression and mitochondrial alterations in thyroid cancer and oxyphilic cell tumors
甲状腺癌和嗜酸细胞肿瘤中 Niban 基因表达和线粒体改变的分子病理学分析
- 批准号:
18590347 - 财政年份:2006
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of the HIV-EP2 gene abnormality in human breast cancer
人类乳腺癌HIV-EP2基因异常分析
- 批准号:
14570165 - 财政年份:2002
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Compression and Consolidation on Compressed Dehydarated Sludge
压缩脱水污泥的压缩固结
- 批准号:
08456119 - 财政年份:1996
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Research on reliability design method of agricultural infrastructures for earthquakes.
农业基础设施抗震可靠性设计方法研究
- 批准号:
06556037 - 财政年份:1994
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Prediction of Behavior of Soft Grounds in Polder Due to Embankment
堤防引起的圩田软土地基性能预测
- 批准号:
04660254 - 财政年份:1992
- 资助金额:
$ 1.98万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
The analysis of the shift from gastric to intestinal phenotype of stem cell in the stomach mucosa
胃粘膜干细胞从胃向肠表型转变的分析
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23590921 - 财政年份:2011
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Analysis of gastric and intestinal phenotype of gastric cancer in asymmetrical cell division
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23790401 - 财政年份:2011
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21790354 - 财政年份:2009
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Gene expression profile of gastric cancer with gastric and intestinal phenotype
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19790261 - 财政年份:2007
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The role of ATBF1 nuclear translocation in gastric and intestinal phenotype and chemosensitivity of gastric cancer
ATBF1核易位在胃癌胃、肠表型及化疗敏感性中的作用
- 批准号:
18590693 - 财政年份:2006
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$ 1.98万 - 项目类别:
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The role of transcription factor ATBF1 for the expression of gastro intestinal phenotype in mucosal cells and gastro inestinal Cancer cells.
转录因子ATBF1在粘膜细胞和胃肠癌细胞表达胃肠表型中的作用。
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13670542 - 财政年份:2001
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$ 1.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)