The study of the mechaniem of bronchial heperresponsiveness the effect of inflammatory cytokines on autononic receptors

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As a clinical research, we measured the ntunber of eosinopils and eosinophil cationic protein (ECP) in the sputum of the patients with bronchial asthma and we compared these data with bronchial hyperresponsiveness, pulmonary functions and their symptoms. We measured the same factors before and after administration of suplatast tosilate (IPD), a Th2 cytokine inhibitor. We also evaluated capsaicin cough threshold, the cough scores and the therapeutic scores. _As results, increased bronchial hyperresponsiveness, small airway diseases and increased ECP concentrations were observed in the patients with bronchial asthma. After administration of IPD cough was decreased and couth threshold improved significantly in thepatients with bronchial asthma. These results were published at the Japanese Society of Allergology Meeting (March 21 to 23, 2002. Makuhari, Chiba, Japan), and will be published at the 97th-ATS meeting (May 19 to 22, 2002, Atlanta, USA).As a basic research, we evaluated the visualization of muscarinic receptors by using positron emission tomography (PET). 11[C]3NMPB, muscarinic receptor antagonist was administered into the vein and body metabolism and distribution were measured and radioactivity in the lungs was counted. Radioactivity of 11[C]3NMPB were detected highly in both lungs suggesting existence of abundant muscarinic receptors in human lung. The part of these results will be publishd at the 42nd Japanese Respiratory Meeting (April 4 to 6, 2002, Sendai) and at the 97th ATS meeting (May 19 to 22, 2002, Atlanta, USA).