Research of Bronchial Hyperresponsiueness : with special reference to neurogenic inflammation and autonomic receptor.

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We have made bronchial asthma model using guinea pigs. We have also evaluated bronchial hyperresponsiveness by capsaicin-induced cough. In this bronchial asthma model, anti-histamine agent ; azelastine and terfenadine inhibited capsaicin-induced cough suggesting inhibition of neurogenic inflammation.We have measured intracelular antigen EG2 in asthmatic patients using a technique in whole-blood flow cytometry. From this study, it is suggested that eosinophil intracellular EG2 is very important factor and correlates the pathophysiological condition of asthma.