Research for the mechanism of bronchinal hyperresponsiveness
支气管高反应性机制研究
基本信息
- 批准号:06670602
- 负责人:
- 金额:$ 1.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1994
- 资助国家:日本
- 起止时间:1994 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We have studied the effect of neurokinin A (NKA) on tracheal smooth muscle (TSM) contraction caused by administration of acetylcholine (ACh) intra-arterially (ia) into the tracheal circulation, or a bilateral stimulation of the vagus nerves in 26 mongrel dogs. As a result, substantial augmentation of tracheal contractile responses to 10^<-10>-10^<-7> molia ACh was obtained 10 min after administration of NKA (p<0.05). Significant potentiation of tracheal contractiion to vagal stimulation for 10-20 Hz was also observed after administration of 10^<-8> mol NKA (p<0.05). We have demonstrated a substantial contractile effect of NKA on canine tracheal smooth muscle that is not related to histamine release from respiratory mast cells. We have also demonstrated that NKA causes augmentation of the parasympathetic tracheal contractile response induced by ia administration of ACh and efferent vagus nerve stimulation. These data suggest that potentiation of vagal contractile response by NKA is related to post-synaptic activation of the parasympathetic nerves.The effect of FK224 on isometric contraction of canine tracheal smooth muscle in situ was studied. Contraction was induced by administration of substance P,neurokinin A,and neurokinin B intra-arterially into the tracheal circulation in five mongrel dogs. FK224 inhibited substance P- and neurokinin A-induced contraction in a dose-dependent manner, but it did not inhibit neurokinin B-induced contraction significantly. These data suggest that FK224 is a sural antagonist of both neurokinin 1 andd neurokinin 2 receptors with a similar potency in in vivo experiments.
本文观察了神经激肽A(NKA)对乙酰胆碱(ACh)经动脉注入26只杂种犬气管循环或刺激双侧迷走神经引起的气管平滑肌(TSM)收缩的影响。结果表明,<-10><-7>NKA给药10分钟后,对10 ~ 10 μ mol/L ACh的气管收缩反应明显增强(p<0.05)。10 μ mol NKA可明显增强迷走神经刺激引起的气管收缩<-8>(p<0.05)。我们已经证明了NKA对犬气管平滑肌的实质性收缩作用与呼吸道肥大细胞释放组胺无关。我们还表明,NKA引起的增强的副交感神经气管收缩反应引起的IA管理的乙酰胆碱和传出迷走神经刺激。上述结果提示NKA增强迷走神经收缩反应与其突触后激活副交感神经有关。通过将P物质、神经激肽A和神经激肽B动脉内注入5只杂种犬的气管循环来诱导收缩。FK 224以剂量依赖性方式抑制P物质和神经激肽A诱导的收缩,但对神经激肽B诱导的收缩无显著抑制作用。这些数据表明,FK 224是神经激肽1和神经激肽2受体的腓肠拮抗剂,在体内实验中具有相似的效力。
项目成果
期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
塩谷隆信,他: "気管支喘息における自律神経異常" 呼吸と循環. 44(I). 47-55 (1996)
Takanobu Shioya 等人:“支气管哮喘的自主神经异常”《呼吸与循环》44(I)。
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加賀谷学 他: "抗コリン薬のムスカリン受容体拮抗作用の選択性" 日本胸部疾患学会雑誌. 32. 302- (1994)
Manabu Kagaya 等:“抗胆碱能药物的毒蕈碱受体拮抗作用的选择性”日本胸科疾病学会杂志 32. 302-(1994)。
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Shioya, T., Kagaya, M., Sano, M., Itaba, M., Shindo, T., Miura, M.: "Bronchodilatory effect of trquizium bromide in patients with COPb" Eur.J.Clin Pharmacol. (in print). (1996)
Shioya, T.、Kagaya, M.、Sano, M.、Itaba, M.、Shindo, T.、Miura, M.:“溴化溴化物对 COPb 患者的支气管扩张作用”Eur.J.Clin Pharmacol。
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Shioya, T., Kagaya, M., Miura, S., Shindo, T., Sano, M., Miura, M.: "Effectiveness of an anti cholinergic agent in elderly patients with bron chial asthma." Arzneimitte Forschng. (in print). (1996)
Shioya, T.、Kagaya, M.、Miura, S.、Shindo, T.、Sano, M.、Miura, M.:“抗胆碱能药物对老年支气管哮喘患者的疗效。”
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塩谷隆信 他: "FK224のNK受容体サブタイプ拮抗作用" 臨床薬理. 25. 145-146 (1994)
Takanobu Shioya 等:“FK224 的 NK 受体亚型拮抗作用”临床药理学 25. 145-146 (1994)。
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SHIOYA Takanobu其他文献
口腔内乾燥や口腔内汚染を呈する患者の咽頭観察.嚥下内視鏡所見での検討.
口腔干燥、口腔污染患者的咽部观察。
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
KAWAGOSHI Atsuyoshi;IWAKURA Masahiro;FURUKAWA Yutaka;SUGAWARA Keiyu;TAKAHASHI Hitomi;SHIOYA Takanobu;稲葉沙枝,坂田理恵子,今西祐子,大西環,柴本勇 - 通讯作者:
稲葉沙枝,坂田理恵子,今西祐子,大西環,柴本勇
SHIOYA Takanobu的其他文献
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{{ truncateString('SHIOYA Takanobu', 18)}}的其他基金
Development of new intervention by nutritional rehabilitation in COPD
慢性阻塞性肺病营养康复新干预措施的开发
- 批准号:
24591124 - 财政年份:2012
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The study of the effect of comprehensive pulmonary rehabilitation in which low-intensity exercise training and nutritional supplementation therapy are combined
低强度运动训练与营养补充治疗相结合的综合肺康复效果研究
- 批准号:
19500440 - 财政年份:2007
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The study of the mechaniem of bronchial heperresponsiveness the effect of inflammatory cytokines on autononic receptors
支气管高反应性机制及炎症细胞因子对自主受体影响的研究
- 批准号:
12670546 - 财政年份:2000
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Research of Bronchial Hyperresponsiueness : with special reference to neurogenic inflammation and autonomic receptor.
支气管高反应性研究:特别涉及神经源性炎症和自主神经受体。
- 批准号:
08670648 - 财政年份:1996
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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