Investigation of New Therapy with Orthostatic Self-Training and Mechanisms for Neurocardiogenic Syncope

神经心源性晕厥立位自我训练新疗法及机制研究

• 批准号: 12670713
• 负责人: ABE Haruhiko
• 金额: $ 1.98万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670713/
• 关键词: Syncope; head-up tilt test; orthostatic training; neurocardiogenic; heart rate variability; follow-up; head-up-tilt試験; orthostatic self-training; ホルター心電図; 神経調整性失神; head-up tilt試験; Tilt training

The purpose of the present study was to investigate the efficacy of home orthostatic self-training program for the prevention of tilt-induced neurocardiogenic syncope. A total of 46 neurocardiogenic syncopal patients, who had experienced spontaneous syncope and were diagnosed by head-up tilt testing (80 degrees for 30 min), were included in the present study. All patients were treated with home orthostatic self-training alone for 30 minutes without any drug therapy and reevaluated within 4 weeks with the same protocol of initial tilt testing. Reevaluated head-up tilt testing could not induce the syncope after the home orthostatic self-training. Heart rate variability after the training showed significant decrease of L/H ratio at the early stage of upright position compared to that before training. All patients were successfully treated with home orthostatic self-training alone without any symptoms such as syncope or presyncope during the long-term follow-up of mean 11 months. We concluded that home orthostatic self-training is a very effective, safe and useful therapeutic option for the prevention of tilt-induced neurocardiogenic syncope.

本研究的目的是探讨家庭立位自我训练计划对预防倾斜诱发的神经心源性晕厥的效果。本研究共纳入46例神经心源性晕厥患者，均发生自发性晕厥，并通过直立倾斜试验（80度，30分钟）诊断。所有患者均接受单独的家庭直立位自我训练30分钟，不接受任何药物治疗，并在4周内使用相同的初始倾斜试验方案进行重新评估。重新评估直立倾斜试验不能诱发家庭立位自我训练后的晕厥。训练后心率变异性显示立位早期L/H比较训练前显著降低。所有患者均成功地进行了家庭立位自我训练，在平均11个月的长期随访期间没有任何症状，如晕厥或晕厥前期。我们的结论是，家庭立位自我训练是一个非常有效，安全和有用的治疗选择，以预防倾斜诱导的神经心源性晕厥。

项目成果

Kikuchi K, ABE H, Nagatomo T, Nakashima Y: "Microdis lodgement as a likely mechanism of pacing failure with high impedance small area electrodes"PACE. (in press).

Kikuchi K、ABE H、Nagatomo T、Nakashima Y：“Microdis 沉积是高阻抗小面积电极起搏失败的一种可能机制”PACE。

Nagatomo T, January CT, Ye B, ABE H, Nakashima Y, *keilski JC: "Rate-dependent QT shortening mechanism for the LQT3 delta mutant"Cardiovasc Res. 54 (3). 624-629 (2002)

Nagatomo T、January CT、Ye B、ABE H、Nakashima Y、*keilski JC：“LQT3 delta 突变体的速率依赖性 QT 缩短机制”Cardiovasc Res。

Oginosawa Y, ABE H, Nakashima Y: "Right pneumothorax resulting from a endocardial screw-in atrial lead in an implantable cardioverter defibrillator system"PACE. 25; 8. 1278-1279 (2002)

Oginosawa Y、ABE H、Nakashima Y：“植入式心律转复除颤器系统中的心内膜旋入式心房导线导致右侧气胸”PACE。

Nagatomo T, ABE H, Oginosawa Y, Araki M, Nakashima Y: "Reproduction of typical electrocardiographic findings of the Brugada syndrome using modified precordial leads"J UOEH. 24. 383-389 (2002)

Nagatomo T、ABE H、Oginosawa Y、Araki M、Nakashima Y：“使用改良的心前导联再现 Brugada 综合征的典型心电图结果”J UOEH。

Kunuigida N, Kohshi K, Kinoushita Y, Katoh T, Abe H et al.: "Radiotherapy after hyperbaric oxygenation improves radioresponse in experimental tumor models"Cancer Left. 26・164. 149-154 (2001)

Kunuigida N、Kohshi K、Kinoushita Y、Katoh T、Abe H 等：“高压氧治疗后的放射治疗改善了实验肿瘤模型的放射反应”Cancer Left 26・164 (2001)。